维生素D在创伤性脑损伤中神经保护作用的研究进展

Review of the neuroprotective role of vitamin D in traumatic brain injury

创伤性脑损伤(TBI)是神经外科最常见的疾病之一,是45岁以下人群中最具威胁的致残、致死因素。TBI能够导致患者的认知功能缺损和精神障碍。近年来,动物实验和临床试验表明,活性形式的维生素D_3(VDH)治疗能够改善TBI导致的认知功能缺损和精神障碍。因此,本文就维生素D的生理作用及VDH在TBI治疗中可能的作用机制进行综述。

Traumatic brain injury （TBI）, one of the most common diseases of nearosurgery, remains high mortality and disability in the population under 45 years. TBI patients suffer permanent cognitive neurological and psychological disabilities. In recent years, basic and clinical experiments have shown that the active form of vitamin D3 （vitamin D hormone, VDH） treatment can improve TBI-induced cognitive impairment and mental disorders. Therefore, in this paper, we focused on the physiological role of vitamin D and the possible mechanism of VDH supplementation following TBI.