血清高迁移率族蛋白1、前列腺素E_2、血管内皮生长因子及白介素与急性淋巴细胞白血病的关系

Relationship between the serum high mobility group box-1 protein,prostaglandin E_2,vascular endothelial growth factor,interleukin and acute lymphoblastic leukemia

目的探究血清高迁移率族蛋白1(HMGB1)、前列腺素E_2(PGE_2)、血管内皮生长因子(VEGF)及白介素(IL)与急性淋巴细胞白血病的关系。方法选取68例急性淋巴细胞白血病患者为观察组,同期68名体检健康同龄者为对照组。比较2组的血清HMGB1、PGE_2、VEGF及IL水平,并将观察组中不同分期与分型急性淋巴细胞白血病患者的血清检测结果进行比较。采用Logistic分析上述血清指标与急性淋巴细胞白血病的关系。结果观察组的血清HMGB1、PGE2、VEGF及IL水平均显著高于对照组,且观察组中不同分期与分型急性淋巴细胞白血病患者的血清检测结果也存在显著差异(P<0.05)。Logistic分析显示,血清HMGB1、PGE_2、VEGF及IL均与急性淋巴细胞白血病有密切的关系(P<0.05)。结论急性淋巴细胞白血病患者的血清HMGB1、PGE_2、VEGF及IL均呈现高表达状态,且不同分期与分型患者的表达差异也较为明显。

Objective To investigate the relationship between the serum high mobility group box-1 protein （ HMGB1 ）, prostaglandin E2 （ PGE2 ）, vascular endothelial growth factor （ VEGF）, interleukin （IL） and acute lymphoblastic leukemia. Methods A total of 68 patients with acute lymphoblastic leukemia were selected as observation group, and 68 healthy people at the same time were selected as control group. The serum HMGB1, PGE2, VEGF and IL levels of two groups were detected and compared, the serum detection results of patients with different stages and types of acute lymphoblastic leukemia were compared in the observation group, and the relationship between those ser- um indexes and acute lymphoblastic leukemia was analyzed by the Logistic analysis. Results The serum HMGB1, PGE2, VEGF and IL levels of observation group were significantly higher than those of the control group, and the serum detection results of patients with different stages and types of acute lymphoblastic leukemia had significant differences in the observation group. Logistic analysis showed that the serum HMGB1, PGE2, VEGF and IL were closely correlated with acute lymphoblastic leukemia （P 〈 0.05）. Conclusion The serum HMGB1, PGE2, VEGF and IL of patients with acute lymphoblastic leukemia are in high expression state, and there are significant differences in patients with different stages and types.