二至丸对凝血—纤溶系统药理作用研究

Study on Pharmacological Effects of Erzhi Pills on Coagulation-fibrinolytic system

目的:探讨二至丸对鼠凝血-纤溶系统的影响。方法:(1)ICR雄性小鼠80只,随机分为空白组、阳性药(氨甲苯酸)组、传统饮片二至丸(高、中、低)剂量组、超微二至丸(高、中、低)剂量组,灌胃7天后,眼眶取血。(2)SD大鼠90只,随机分为空白组、模型组、阳性药组、传统饮片二至丸(高、中、低)剂量组、超微二至丸(高、中、低)剂量组,灌胃3天后,静脉取血。检测(1)、(2)的凝血原时间(PT)、组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活物抑制剂(PAI)活性。结果:二至丸超微高、中剂量组和传统高剂量组可明显提升正常小鼠和模型大鼠PAI的活性、降低PT。结论:超微处理后二至丸的药效明显提高。

Objective ： To investigate the effect of Erzhi pills on coagulation and fibrinolysis in rats. Methods：①80 ICR male mice were randomly divided into blank group, positive medicine（Aminonethylbenzoic Acid） group, traditional Pieces Erzhi pills（high, medium and low） dose group,uhrastructural Erzhi pills（high, medium and low）, after 7 days of intragastric administration, eyes to take blood.②90 rats were randomly divided into blank group, model group, positive drug group, traditional Pieces Erzhi pills（ high, medium and low） dose group, uhrastructural Erzhi pills（high, medium and low）, after 3 days of intragastric administration, venous blood. Detection of ①, ② of prothrombintime （ PT）, tissue type plasminogen activator （ t PA）, plasminogen activator inhibitor （PAI）. Results：The activity of PAl in normal mice and model rats was significantly improved by Erzhi pills ultramicro, middle dose group and traditional high dose group. Conclusion ： The efficacy of Erzhi pills after treatment was significantly improved.