复方苦参注射液联合化疗治疗急性白血病临床疗效观察

Clinical effect of compound matrine injection combined with chemotherapy in the treatment of acute leukemia

目的:探讨复方苦参注射液联合化疗治疗急性白血病的临床效果,为临床上急性白血病的治疗提供依据。方法:选择64例急性白血病患者共为研究对象,将其随机分为观察组与对照组,每组各32例,观察组患者采用复方苦参注射液联合化疗治疗,对照组患者采用单纯化疗治疗。疗程结束后对两组患者临床缓解率、KPS功能状态评分及不良反应发生情况进行对比分析。结果:观察者患者治疗后总有效率(75.0%)高于对照组患者(53.1%),差异有统计学意义(P<0.05)。治疗后,观察者患者KPS功能状态评分高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后不良反应发生情况差异不明显(P>0.05)。结论:复方苦参注射液联合化疗可有效提高急性白血病患者的临床缓解率,并能改善患者的健康状态,且不增加患者的不良反应,因此我们认为临床上应用复方苦参注射液治疗急性白血病是有效、安全的。

Objective： To investigate the clinical effect of compound matrine injection combined with chemotherapy in the treatment of acute leukemia, and provide the basis for the clinical treatment of acute leukemia. Methods ： Treatment of acute leukemia patients were randomly divided into observation group and control group, 32 cases in each group, the observation group were treated with compound matrine injection combined with chemotherapy, the control group were treated with simple chemotherapy. After the treat- ment, the clinical remission rate, KPS functional status score and adverse reactions of the two groups were compared and analyzed. Results：The total effective rate （75 ~ ） was higher than that of the control group （53.1 G ）, and the difference was statistically sig- nificant （P^0.05）. After treatment, the functional status of KPS in the patients was significantly higher than that in the control group （P＇~0.05）. There were no significant differences in adverse reactions between the two groups after treatment （P~〉0.05）. Conclusion：Compound matrine injection combined with chemotherapy can effectively improve the clinical remission rate of acute leukemia patients, and can improve the patient＇s health status, and does not increase the adverse reaction, so we believe that the clinical application of compound matrine injection in the treatment of acute leukemia is effective and safe.