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Klotho蛋白通过Wnt/β-catenin信号通路下调高磷诱导的大鼠成骨细胞分泌成纤维细胞生长因子23 被引量:1

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摘要 成纤维细胞生长因子23(FGF23)升高的CKD患者全因死亡率增加,左室射血分数降低,是左室肥厚的独立危险因素,而可溶性Klotho蛋白与血清FGF23呈负相关。本研究拟通过重组小鼠Klotho蛋白干预高磷刺激的成骨细胞,观察Klotho蛋白对大鼠成骨细胞分泌FGF23的影响,并对其作用机制做初步探讨。
出处 《中华肾脏病杂志》 CSCD 北大核心 2017年第5期385-387,共3页 Chinese Journal of Nephrology
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