摘要
目的:分析退银汤对寻常性银屑病(Psoriasis Vulgaris,PV)患者外周血中胎盘型钙黏蛋白(P-cad)及中性粒细胞弹性蛋白酶(NE)表达水平的影响。方法:41例PV患者为实验组,41例健康志愿者为对照组。采用酶联免疫吸附竞争法检测PV患者使用退银汤前后外周血P-cad水平和NE水平。结果:治疗前P-cad实验组(47.05±11.14)ng/mL,对照组(10.93±6.77)ng/mL,实验组P-cad水平高于对照组(P<0.05)。治疗后实验组P-cad水平低于本组治疗前(P<0.05)。治疗前实验组NE(16.92±3.31)mg/L,对照组(3.66±1.48)mg/L,实验组NE高于对照组(P<0.05)。治疗后实验组NE指标低于本组治疗前(P<0.05)。结论:退银汤能够显著降低寻常性银屑病患者外周血P-cad及NE表达水平。
Objective: To analysis the effect of Tuiyin Decoction on the expression level of P-cad in peripheral blood and NE index of psoriasis vulgaris (PV) patients. Method: There were 41 cases of PV patients in the study group and 41 cases of healthy volunteers in the control group. The level of P-cad in peripheral blood and NE index of PV patients before and after using Tuiyin Decoction was detected by competing-ELISA. Result: Before the treatment, the level of P-cad of the study group was ( 47.05 ± 11.14 ) ng/mL while that of the control group was ( 10.93 ± 6.77 ) ng/mL. The level of P-cad of the study group was higher than that of the control group ( P〈0.05 ) .The level of P-cad of the study group after the treatment was lower than that before the treatment ( P〈0.05 ) . Before the treatment, the level of NE of the study group was ( 16.92 ± 3.31 ) ng/mL while that of the control group was ( 3.66 ± 1.48 ) ng/mL. The level of NE of the study groupwas higher than that of the control group ( P〈0.05 ) . The level of NE of the study group after the treatment was lower than that before the treatment ( P〈0.05 ) . Conclusion: Tuiyin Decoction could decrease the expression level of P-cad in peripheral blood and NE index of PV patients significantly.
出处
《实用中医药杂志》
2017年第6期609-610,共2页
Journal of Practical Traditional Chinese Medicine
关键词
寻常性银屑病
退银汤
外周血P-cad
NE
Psoriasis vulgaris
Tuiyin Decoction
P-cad in peripheral blood
NE index