舌下含服标准化尘螨变应原疫苗滴剂治疗荨麻疹的临床观察

Clinical observation of standardized sublingual dermatophagoides farinae allergen vaccine drops in treatment of urticaria

目的探究以标准化尘螨变应原疫苗滴剂舌下含服治疗粉尘螨过敏荨麻疹患者的效果。方法入选研究对象为2015年8月~2016年7月期间我院皮肤科收治的86例粉尘螨过敏致荨麻疹者,随机将患者分为一般组(枸地氯雷他定)、观察组(加用标准化尘螨滴剂),每组均为43例,对比用药前后患者风团数目、瘙痒情况,评估疾病治疗效果。结果观察组症状改善率为97.7%,明显高于一般组88.4%,观察组改善效果更优,差异具有统计学意义(P<0.05);入院时两组风团数目、瘙痒程度比较,差异无统计学意义(P>0.05),用药后风团数目、瘙痒程度改善情况观察组优于一般组,差异具有统计学意义(P<0.05)。结论临床对由粉尘螨引发的荨麻疹以标准化尘螨滴剂舌下含服治疗,患者症状改善效果好、疗效佳。

Objective To explore the effect of standardized sublingual dermatophagoides farinae allergen vaccine drops in treatment of patients with urticarial caused by dust mite sensitivity. Methods 86 patients with urticarial caused by dust mite sensitivity who were admitted to department of dermatology in our hospital from August 2015 to July 2016 were selected as research objects. They were randomly allocated to the ordinarygroup and the observation group, with 43 in each. The ordinary group was given desloratadine citrate disodium and the observation group was given desloratadine citrate disodium combined with standardized dermatophagoides farinae drops. The number of wheals and itching status before and after medication of patients were compared to evaluate the curative effect of disease. Results Ameliorative rate of symptom of the observation group was 97.7%, significantly higher than that of the ordinary group 88.4%. Improvement effect of the observation group was superior and the difference was statistically significant （P 〈 0.05）. Difference in the number of wheals and itching status at admission of two groups had no statistical significance （P ~ 0.05）. After medication, improvements of the number of wheals and itching status in the observation group were superior to those of the ordinary group. The difference was statistically significant （P 〈 0.05）. Conclusion In clinic, sublingual dermatophagoides farinae allergen vaccine drops in treatment of patients with urticarial caused by dust mite sensitivity has better improvements of symptoms and curative effects.