卡托普利降低脑梗死复发危险因素的研究

Study on risk factors of cutting down relapse of cerebral arterial thrombosis in the elderly with captopril

目的血管紧张素转换酶抑制剂卡托普利降低脑卒中复发危险因素的研究。方法选择2012年10月~2014年10月我院就诊的老年卒中患者160例,随机分为在抗血小板聚集、他汀的基础上加用卡托普利组80例为观察组,仅使用抗血小板聚集、他汀药物80例为对照组,对比治疗前、治疗1、6及24个月时两组患者的实验室指标。24个月时统计两组缺血卒中的复发和病死情况,以CT、MRI平扫出现新的缺血梗塞灶为准。结果观察组患者的收缩期血压、舒张期血压、血清甘油三脂测定、低密度脂蛋白、胆固醇测定均显著低于对照组(P<0.01);观察组的复发率和病死率明显较对照组低(P<0.05)。结论卡托普利对缺血性脑卒中二级预防有效、能降低脑卒中患者复发率。

Objective To explore the effect of captopril cutting down the relapse of cerebral arterial thrombosis. Methods 160 cases of elderly stroke patients cured in our hospital from October 2012 to October 2014 were selected and randomly divided into observation group （ treated with captopril adding platelet aggregation and statin, 80 cases） and control group （only use of platelet aggregation and statin, 80 cases）. Different indexes of laboratory in the times of pretherapy, the first month, the sixth month and the twenty-fourth month were compared between the two groups. In the twenty-fourth month, the recurrence and mortality of the two groups were computed, with subject to CT or MRI plain scan appearing new ischemic infarction. Results The indexes of Systolic blood pressure, diastolic blood pressure, serum triglyceride, low density lipoprotein and cholesterol in the observation group were much lower than those in control group （P 〈0.01）. The relapse rate and fatality rate of the observation group were obviously lower than those of control group （P 〈 0.05）. Conclusion Captopril can effectively carry out secondary prevention of cerebral arterial thrombosis, and cut down the relapse rate of stroke patients.