成纤维细胞在皮肤衰老中的作用机制研究进展

Research progress on mechanism of action of fibroblasts in skin aging

在过去的20余年间,对皮肤衰老机制的探索是一个生命科学研究领域的热门话题。皮肤真皮中最重要的细胞成分是成纤维细胞,它与组织创伤修复密切相关。皮肤衰老与成纤维细胞数量减少、形态改变、分泌合成功能减弱或衰退等有关。研究成纤维细胞在皮肤衰老中的作用机制,包括ROS-PTEN-PI3K、Smad3-I型胶原蛋白、miRNAs等,为研究预防和延缓皮肤衰老提供新的思路以及指导意义。该文就成纤维细胞在皮肤衰老中的作用机制进行综述。

In the past more than 20 years, to explore the mechanism of skin aging is a hot topic in the field of life science research. The most important cellular component in the dermis is fibroblasts, which is closely related to tissue repair. Skin aging is associated with the decrease in the number of fibroblasts, as well as the changes in morphology and the decrease of the secretion and synthetic function of the fibroblasts. To study the mechanism of action of fibroblasts in skin aging, including ROS-PTEN-PI3K, Smad3-I type collagen, miRNAs and so on, maybe provides a new way of thinking for preventing and delaying skin aging. In this paper, the mechanism of action of fibroblasts in skin aging was reviewed.