乙酰半胱氨酸对COPD稳定期患者氧化应激及细胞因子的影响

Effect of acetylcysteine on oxidative stress and serum cytokines in patients with stable COPD

目的:观察乙酰半胱氨酸治疗慢性阻塞性肺疾病(COPD)稳定期患者氧化应激指标及外周血细胞因子TNF-α、IL-8指标的影响。方法:选择我院门诊收治的COPD稳定期患者60例为研究对象。将患者随机分为对照组和治疗组,每组30例。对照组患者给予常规治疗,观察组在常规治疗基础上加予乙酰半胱氨酸口服,疗程12个月。在治疗前及治疗后6、12个月,检测两组患者氧化应激指标SOD、MDA及血清细胞因子TNF-α、IL-8水平的变化。结果:在治疗前,两组患者血清TNF-α、IL-8、SOD、MDA水平比较,差异无统计学意义(P>0.05)。在治疗后6、12个月,治疗组患者细胞因子指标(TNF-α、IL-8)以及氧化应激损伤标记物MDA水平均低于观察组(P<0.05),SOD水平较观察组上升(P<0.05)。结论:乙酰半胱氨酸具有降低COPD患者氧化应激损伤的作用,并能够抑制炎症因子,对于COPD稳定期患者具有一定治疗作用。

Objective：To observe the effects of acetylcysteine on oxidative stress and serum cytokine levels in patients with stable chronic obstructive pulmonary disease（COPD）.Methods：Sixty patients with stable COPD,treated in our hospital on outpatient basis,were enrolled and equally randomized into control group and treatment group.The control group received conventional therapy,and the treatment group were given additional oral acetylcysteine besides conventional therapy regimen.The therapy course was 12 months.Levels of serum superoxide dismutase（SOD）,malondialdehyde（MDA）,TNF-α and IL-8 were measured in two groups before therapy and at the 6th and 12th month following medication.Results：Serum TNF-α,IL-8,MDA and SOD had no significant difference between groups before therapy（P〉0.05）,yet the treatment group had significantly lower levels of serum TNF-α,IL-8 and MDA and higher SOD by the 6th and 12th month after medication,as compared to the control group（P〈0.05）.Conclusion：Acetylcysteine can reduce the oxidative level in patients with stable COPD,and inhibit the inflammation factors,suggesting that this agent may be critical role in the treatment of COPD at stable stage.