肺癌患者血小板参数的临床意义

Clinical value of platelet parameters in patients with lung cancer

目的评价血小板参数检测在肺癌中的应用价值。方法分别检测102例肺癌患者、32例肺部良性肿瘤患者以及40名健康对照者血小板计数(PLT)、血小板压积(PCT)、血小板平均体积(MPV)以及血小板体积分布宽度(PDW)水平。结果肺癌组PLT、PCT、MPV水平均显著高于健康对照组和肺部良性肿瘤组(P<0.05),而PDW水平差异无统计学意义(P>0.05)。肺腺癌患者的MPV、PDW与其他类型肺癌比较差异无统计学意义(P>0.05),但腺癌患者的PLT、PCT显著低于鳞癌、小细胞癌和大细胞癌患者(P<0.05)。Ⅳ期肺癌患者的PLT、PCT、MPV水平均高于Ⅰ期、Ⅱ期和Ⅲ期肺癌患者(P<0.05)。结论肺癌患者的PLT、PCT、MPV水平是升高的,并且TNM分期越高,PLT、PCT、MPV水平越高,检测血小板参数有助于判断肺癌的预后情况和病情进展情况。

Objective To evaluate the application value of platelet parameters in patients with lung cancer.Methods The samples from 102 patients with lung cancer, 32 patients with benign tumors and 40 healthy controls were determined for the levels of platelet count（PLT）, platelethematocrit（PCT）, mean platelet volume（MPV）, and platelet distribution width（PDW）. Results In the lung cancer group, the levels of PLT, PCT, and MPV were significantly higher than those in either the healthy control group or benign tumor group（P〈0.05）, while PDW had no statistically significant difference among these groups（P〉0.05）. The levels of MPV and PDW in the patients with lung adenocarcinomashad had no significant diffrencecompared with those in the patients with other kinds of lung cancer（P〉0.05）. The levels of PLT and PCT in the patients with lung adenocarcinomas were lower than those in the patients with other kinds of lung cancer（P〈0.05）.The levels of PLT, PCT, and MPV inthe TNM-stage IV lung cancer patients were significantly higher than those in the stage I, II and III lung cancer patients（P〈0.05）. Conclusion The levels of PLT, PCT, and MPV in patients with lung cancer are related to TNM stages. It is useful to measure platelet parameters in patients with lung cancer for the evaluation of disease status.