后部皮层萎缩的研究进展

Progress in posterior cortical atrophy research

后部皮层萎缩(posterior cortical atrophy,PCA)是一种神经退行性痴呆,临床表现以视知觉、视空间、读写能力和实践技能进行性下降为特点。神经影像学检查可见突出的PCA和代谢降低,最常见的病理表现是后部皮层的淀粉样斑块沉积和神经原纤维缠结,因此普遍认为PCA是阿尔茨海默病的一种变异型。

Posterior cortical atrophy （PCA） is a kind of neurodegenerative dementia, which is characterized by the progressive decline of visuoperceptual,visuospatial, reading and writing ability and praxic skills. Neuroimaging usually shows atrophy or metabolic decrease in posterior brain regions. The most common neuropathologic changes of PCA are amyloid plaques deposition and neurofibrillary tangles in posterior cortex. In general,PCA is considered as a variant form of Alzheimer＇s disease.