摘要
Chan-Evans-Lam偶联反应在20世纪90年代被发现以后经历了突飞猛进的发展.Chan-Evans-Lam偶联反应作为一类条件温和、高效、官能团兼容性好的偶联方法,不仅被广泛地应用于各种碳-杂键、碳-碳键的形成反应中,也成功地应用于复杂天然产物的全合成中.综述了近5年来Chan-Evans-Lam偶联反应在有机合成中发展的新策略及其在天然产物全合成中的应用.
Chan-Evans-Lam reaction has been served as a powerful cross-coupling reaction in organic synthesis since its dis- covery in the 1990s owing to the feature of mild reaction conditions, functional group tolerance and open-flask chemistry. Up to now, it has been not only extensively utilized in carbon-heteroatom or carbon-carbon bonds formation, but also successfully applied to synthesize natural products and alkaloids. The new strategies of Chan-Evans-Lam reaction in organic synthesis as well as applications in total synthesis in recent five years are discussesed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第5期1069-1087,共19页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21562005
21602037)
广西高校百人计划
广西自然科学基金(No.2016GXNSFFA380005)资助项目~~
关键词
偶联反应
铜催化
有机硼试剂
碳-杂键形成
coupling reaction
copper-catalyzed
organic boron reagents
carbon-heteroatom bond formation
