摘要
报道了一种负载钯纳米颗粒催化多种芳基酯与季铵盐经由两次C—N键活化的,选择性合成酰胺的胺解反应.在这个反应中,Pd/γ-Al_2O_3催化剂表现出卓越的催化活性和空气中至少五次循环的重复利用性.试验结果表明季铵盐的第一次C—N键断裂得到卤代烷和三级胺,第二次C—N键断裂是通过产生亚胺离子中间体完成的.
Catalyzed by supported palladium nanoparticles, an aminolysis reaction between various aryl esters and quaternary ammonium salts via twice C--N bond activations has been developed for selectively synthesis of amides. The Pd/）,-A1203 cat- alyst exhibited an excellent catalytic activity and reusability of at least five recycles in air for the reaction. The experiment results indicated that the first C--N cleavage of quaternary ammonium salt affords the tertiary amine and halohydrocarbon, and the second C--N cleavage proceeds via the formation of an iminium intermediate.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第5期1220-1230,共11页
Chinese Journal of Organic Chemistry
基金
supported by the National Natural Science Foundation of China(No.21462031)
the Initial Special Research for National Basic Research Program of China(No.2014CB460609)
the Research Program of Science and Technology at University of Inner Mongolia Autonomous Region(No.NJZZ14032)~~
关键词
季铵盐
胺解
钯
C—N活化
芳基酯
quaternary ammonium salts
aminolysis
palladium
C--N activation
aryl esters
