糖尿病合并急性脑梗死患者血清中细胞因子及同型半胱氨酸的关系研究

The relationship among cytokines and homocysteine in diabetes patients complicating with acute cerebral infarction

目的:探讨糖尿病合并急性脑梗死患者中细胞因子(M-CSF、ox-LDL、sICAM-1)及同型半胱氨酸(Hcy)与脑梗死的关系,为进一步明确糖尿病合并急性脑梗死的发病机制提供依据。方法:选取糖尿病合并急性脑梗死患者(A组)和非糖尿病性急性脑梗死患者(B组)各50例及体检健康对照者100名(C组),应用酶联免疫吸附测定法测定细胞因子和Hcy水平及彩色超声等进行检验并比较。结果:A组细胞因子和Hcy水平均较C组高(P<0.01);Pearson关联性分析提示,细胞因子与Hcy无显著关联性(P>0.05)。结论:细胞因子及同型半胱氨酸在糖尿病患者动脉粥样硬化导致脑梗死过程中可能起重要作用;高同型半胱氨酸血症可能是导致脑梗死患者sICAM-1不同程度升高的原因之一。

Objective： To investigate the relationship among cytokines such as macrophage colony-stimulating factor （M-CSF）, oxidative modification of low density lipoprotein （ox-LDL）, soluble intercellular adhesion molecule-1 （sICAM-1） and homocysteine （Hcy） in diabetes with acute cerebral infarction so as to provide reference for further understanding the pathogenesis of diabetes with acute cerebral infarction. Methods： One hundred inpatients with acute cerebral infarction were selected and divided into groups A （with diabetes mellitus）and B （without diabetes mellitus） with 50 cases each. Meanwhile, one hundred healthy subjects were selected as group C （control group） from the department of physical examination. Cytokines and Hcy levels were determined by enzyme-linked immunosorbent assay and body examination was performed by color Doppler ultrasound. Results： Cytokines and Hcy levels were higher in group A than in group C （P〈0.01）. Pearson correlation analysis showed that there was no significant correlation among cytokines and Hcy （P〉0.05）. Conclusions： Cytokines and Hcy may play an important role in acute cerebral infarction caused by artery atherosclerosis in diabetes mellitus patients, and hyperhomocysteinemia may be one of the causes for the increased sICAM-1 in patients with cerebral infarction.