肾病综合征患者血清免疫球蛋白和补体检测的临床意义

Clinical significance of serum immunoglobulin and complement detection in patients with nephrotic syndrome

目的探讨检测血清免疫球蛋白和补体用于肾病综合症患者临床诊断与治疗中的意义与应用方法。方法收集2015年1月-7月本院住院的58例肾病综合症患者作为观察组,另收集同期健康体检者56例作为对照组。采用免疫比浊法来测量每份样本的补体成分(C3、C4)和血清免疫球蛋白(IgA、IgG与IgM),并进行分析比较。结果两组研究对象血清补体C4含量差异无统计学意义(P>0.05);观察组血清补体C3值低于对照组,差异有统计学意义(P<0.05)。观察组血清中IgA与IgG值低于对照组,而观察组血清中IgM值高于对照组,差异均有统计学意义(P<0.05)。结论血清免疫球蛋白和补体检测在肾病综合症诊断和治疗过程中具有一定的指导性,值得推广应用。

Objective To explore the significance and application methods of the detection of serum immunoglobulin and com- plement for patients with nephrotic syndrome in clinical diagnosis and treatment. Methods From January 2015 to July 2015, 58 patients with nephrotic syndrome were enrolled in our hospital as an observation group. During this period, 56 healthy sub- jects were examined as controls. （C3, C4） and serum immunoglobulin（ IgA, IgG and IgM） were measured by immunoturbidim- etry, and the results were compared and analyzed statistically. Results There was no statistical significance on the difference of serum complement C4 level between the two groups（ P 〉 0.05 ）. The serum C3 level in the observation group was lower than that in the control group, with the difference statistically significant （ P 〈 0.05 ）. The serum IgA and IgG in the observation group were lower than those in the control group, while the serum IgM value in the observation group was higher than that in the con- trol group, with the difference statistically significant （P 〈 0.05 ）. Conclusion Serum immunoglobulin and complement detec- tion in the diagnosis and treatment of nephrotic syndrome has a certain degree of guidance, and it is worthy of popularization and application.