早期智力干预联合神经节苷脂治疗新生儿缺氧缺血性脑病的效果

Effect of early intelligence intervention combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy

目的探讨早期智力干预联合神经节苷脂治疗新生儿缺氧缺血性脑病的效果。方法选取2015年5月~2016年10月我院收治的120例新生儿缺氧缺血性脑病患儿,采用随机数字表法将其分为对照组和观察组,各60例。对照组行神经节苷脂治疗,观察组在神经节苷脂治疗的基础上联合早期智力干预,比较两组患者的治疗效果。结果观察组治疗的总有效率为96.7%,与对照组的85.0%比较,差异有统计学意义(P<0.05);观察组满意度为98.3%,与对照组的86.7%比较,差异有统计学意义(P<0.05);观察组患者DQ评分及神经行为评分均优于对照组,差异有统计学意义(P<0.05)。结论采用早期智力干预联合神经节苷脂治疗新生儿缺氧缺血性脑病,能够较好地促进患儿神经系统的发育,改善患儿感知认知水平,进而改善患儿预后,应用价值较高。

Objective To investigate the effect of early intelligence intervention combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy （HIE）.Methods 120 cases of neonatal hypoxic ischemic en- cephalopathy （HIE） in our hospital from May 2015 to October 2016 were selected and randomly divided into two groups：control group and observation group,60 in each group.The control group was treated with ganglioside treatment, while the observation group was given early intelligence intervention on the basis of ganglioside treatment,and the final treatment effect of the two groups were compared.Results The total effective rate of the observation group was 96.7%, compared with 85.0% in the control group,with significant difference （P〈0.05）;satisfaction of the observation group was 98.3%,compared with 86.7% in the control group,with significant difference （P〈0.05）;the DQ score and neurological score of the patients in the observation group were better than the control group,the differences were statistically significant （P〈 0.05）.Conclusion The early intelligence intervention combined with ganglioside treatment of neonatal hypoxic-ischemic encephalopathy can promote the development of the nervous system of children,improve children＇s perception of cogni- tive level,and improve the prognosis,with higher application value.