生长抑素联合泮托拉唑治疗重症急性胰腺炎的效果

Effect of Somatostatin combined with Pantoprazole in the treatment of severe acute pancreatitis

目的探究生长抑素联合泮托拉唑治疗重症急性胰腺炎(SAP)的疗效及对炎性因子的影响。方法选取2014年9月~2016年6月我院收治的84例SAP患者为研究对象,根据不同治疗方法分成对照组和观察组各42例。对照组在常规治疗基础上给予泮托拉唑治疗;观察组采用半托拉唑联合生长抑素治疗。比较两组治疗效果及治疗前后炎性因子水平。结果观察组总有效率为95.24%,较对照组的80.95%高,差异有统计学意义(P<0.05);治疗前两组炎性因子水平无显著差异(P>0.05),治疗后两组炎性因子水平均低于同组治疗前,差异有统计学意义(P<0.05)。观察组治疗后hs-CRP、TNF-α和IL-6水平同对照组治疗后比较,明显较低,差异有统计学意义(P<0.05)。结论生长抑素联合泮托拉唑治疗SAP,效果确切,并能有效降低炎性因子水平,促进症状改善,值得临床推广。

Objeetive To probe into the clinical effects of Somatostatin combined with Pantoprazole in the treatment of severe acute pancreatitis （SAP）and influence of inflammatory factor.Methods 84 cases of patients with SAP and who accepted treatments, in our hospital from September 2014 to June 2016 were selected as the research objects, and were divided into the control group of 42 cases and the observation group of 42 cases by the different treatment methods.The control group were given Pantoprazole on the basis of routine treatment,while the observation group was treated with pantoprazole combined with Somatostatin.Then,the treatment effect and the level of inflammatory factors before and af- ter treatment of two groups of patients were compared.Results The results Showed that the total effective rate in the ob servation group was 95.24%, which was significantly higher than that in the control group （80.95%）,and the difference was statistically significant （P〈0.05）;there was no significant difference in the levels Of inflammatory factors between the two groups before treatment （P〉0.05）,after treatment, the levels of inflammatory factors in the two groups were lower than those in the same group before treatment, the difference was statistically significant （P〈0.05）;the levels of hs-CRP, TNF-α and IL-6 in the observation group were significantly lower than those in the control group, the difference was statistically significant （P〈0.05）.Conclusion The effect of Somatostatin combined with Pantoprazole in the treatment of SAP are exact,which can effectively reduce the level of inflammatory factors, promote the improvement of symptoms,thus it is worth promoting.