绝经后女性脑梗死患者血清抵抗素的相关研究

Correlation study on serum resistin in postmenopausal female with cerebral infarction

目的探讨绝经后女性脑梗死患者与血清抵抗素的相关性方法选择2015年6月~2016年6月我院接诊的40例女性脑梗死患者为研究对象,选择同期我院接诊的40例女性健康体检者作为对照组,均已绝经。比较两组的血清抵抗素、空腹胰岛素、血压、血糖、血脂、超敏C反应蛋白(hs-CRP)及胰岛素敏感性。结果两组的收缩压(SBP)、舒张压(DBP)、血清抵抗素、胰岛素、胰岛素敏感性、空腹血糖(FBG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP比较差异均有统计学意义(P<0.01),两组的三酰甘油(TG)、总胆固醇(TC)比较差异无统计学意义(P>0.05);单因素分析结果中,血清抵抗素与SBP、DBP、胰岛素、FBG、LDL-C、hs-CRP成正相关(P<0.05),与胰岛素敏感性、HDL-C成负相关(P<0.05);将抵抗素作为因变量,其余指标作为自变量,在多因素分析结果中显示,血清抵抗素和LDL-C、hs-CRP成正相关(P<0.05),与胰岛素敏感性、HDL-C成负相关(P<0.05)。结论在绝经后女性脑梗死患者中,血清抵抗素水平呈明显升高表达,升高原因可能与体内炎症激活有关。

Objective To study correlation study on serum resistin in postmenopausal female with cerebral infarction. Methods 40 patients of female cerebral infarction who received therapy from June 2015 to June 2016 in our hospital were selected as research objects,and 40 female patients who were admitted to our hospital during the same period were selected as control group,they all were menopause.The serum resistin,fasting insulin,blood pressure,blood glucose,blood lipids,high sensitive C reactive protein （hs-CRP） and insulin sensitivity were compared between the two groups.Results There were significant differences in systolic blood pressure （SBP）,diastolic pressure （DBP）,serum resistin ,insulin,in- sulin sensitivity,fasting plasma glucose （FBG）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）,hs-CRP between the two groups （P〈0.01） and there was no significant difference in the triglyceride （TG）,total cholesterol （TC） between the two groups （P〉0.05）.In the f single factor analysis,the serum resistin was posi- tively correlated with SBP,DBP,insulin,FBG,LDL-C and hs-CRP （P〈0.05）,and negatively correlated with insulin sensi- tivity and HDL-C （P〈0.05）.Resistin as a dependent variable,the remaining indicators as independent variables,in the multivariate analysis,the serum resistin was positively correlated with insulin SBP,LDL-C and hs-CRP （P〈0.05）,and negatively correlated with insulin sensitivity and HDL-C （P〈0.05）.Conclusion In the postmenopausal female with cere- bral infarction,serum resistin levels were significantly increased,the cause of the increase may be related to the inflam- matory activation in vivo.