妊娠高血压疾病患者凝血相关指标的改变及临床意义

Changes of coagulation-related indexes in patients with pregnancy-induced hypertension and its clinical significance

目的分析和探讨妊娠高血压疾病患者凝血相关指标的改变及临床意义。方法选择2015年1月~2016年12月我院收治的300例妊娠高血压疾病患者为研究对象,将其中120例为妊娠期高血压患者设为甲组,108例轻度子痫前期患者设为乙组,72例重度子痫前期患者设为丙组。选择同期60名健康的足月妊娠孕妇作为正常晚孕组。对各组的凝血活酶时间(APTT)、纤维蛋白原(FBG)、凝血酶原时间(PT)、抗凝血酶Ⅲ(AT-Ⅲ)、凝血酶时间(TT)、凝血酶原时间国际化标准比值(PT-INR)、胆固醇(TC)、三酰甘油(TG)、血小板压积(PCT)、血小板平均分布宽度(PDW)、血小板计数(PLT)、血小板平均体积(MPV)进行观察和比较。结果与正常晚孕组比较,甲、乙、丙三组APTT、PT、AT-Ⅲ、PT-INR、PLT均显著下降,差异均有统计学意义(P<0.05),且PT在甲组、乙组、丙组依次递减。与正常晚孕组比较,甲、乙、丙三组FBG、TG、PDW、MPV均显著升高,差异均有统计学意义(P<0.05),且MPV在甲组、乙组、丙组依次递增。各组TT、TC、PCT比较,差异无统计学意义(P>0.05)。结论对于妊娠高血压疾病患者而言,病情越重越容易出现凝血状态,越容易形成血栓。

Objective To analyze and explore the changes and clinical significance of coagulation-related indexes in patients with pregnancy-induced hypertension.Methods From January 2015 to December 2016,300 patients with preg- nancy-induced hypertension admitted into our hospital were selected as research objects.Among them,120 patients di- agnosed as gestational hypertension were classified into group A,108 patients with mild preeclampsia were set as group B,and the rest 72 severe preeclampsia patients were set as group C.After that,60 healthy pregnant women in full term during the same period were set as normal late pregnancy group.The activated partial thromboplastin time （APTT）,fibrinogen （FBG）,prothrombin time （PT）,antithrombinIII （AT-III ）,thrombin time （TT）,PT-INR,total cholesterol （TC）,triglyceride triglyceride （TG）,thrombocytocrit （PCT）,platelet distributing width （PDW）,platelet count （PLT）,and mean platetet volume （MPV） were observed and compared in these groups.Results Compared with the normal late pregnancy group,APIT,PT, AT-HI,PT-INR,and PLT of the group A,B,and C were all greatly decreased,the differences were statistically significant （P〈0.05）.The PT was gradually decreased in group A,B,and C.In comparison of the normal late pregnancy group,FBG, TG,PDW,and MPV were all markedly increased,the differences were statistically significant （P〈0.05）.MPV was gradually increased in group A,B,and C accordingly.There was no significant difference in TT,TC,PCT （P〉0.05）.Conclusion For patients with pregnancy-induced hypertension,the more severe the disease condition is,the easier coagulation becomes as well as thrombogenesis.