抗肿瘤化合物告达亭的早期毒性机制研究

Study on the Early Toxicity and Mechanism for Antitumor Compound Caudatin

为探究告达亭(Caudatin)对雄性昆明小鼠的毒性影响,按照告达亭质量比为5和10 mg/kg以及溶剂对照组对SPF级昆明鼠通过腹腔注射的方法,进行为期14 d的毒理学研究.实验动物总共30只昆明鼠,随机分为6组,分2批进行实验,两次实验结果一致:实验昆明鼠在不同浓度告达亭处理14 d后体质量无明显变化,血液学指标检测正常,心、肝、肺、肾以及睾丸均无组织畸变.

To examine the toxic effect of Caudatin on male Kunming mice, using Caudatin concentrations of 5 mg/kg, 10 mg/kg and the vehicle control group of SPF grade Kunming mice by intraperitoneal injection method, we conducted the toxicological study for a period of 14 days. These 30 Kunming mice were randomly divided into six groups, within two sub-experiments. We found that the results from these two sub-experiments are consistent with each other. There was no significant change in body weight and hematological parameters. We observed no markedly pathological change in the tissue of heart, liver, lung, kidney and testis of 30 Kunming mice after the treatment of different concentrations of Caudatin for 14 days.