非小细胞肺癌骨转移特征与预后的相关性

The Characteristics of Non-Small Cell Lung Cancer with Bone Metastasis and Relationship with Clinical Prognosis

[目的]分析非小细胞肺癌(non-small cell lung cancer,NSCLC)骨转移的临床特征及影响预后生存的相关因素。[方法]回顾性分析辽宁省肿瘤医院2011年6月至2014年6月确诊非小细胞肺癌患者117例,统计其6个月、1年、2年生存率,并计算中位生存期(median overall survival,m OS),分析影响骨转移患者生存的预后因素。[结果 ]在PS评分低或高(15.1m vs 11.6m)、骨转移灶单病灶或多病灶(15.7m vs 11.9m)、中轴骨或四肢骨转移(14.9m vs11.2m)、双膦酸盐治疗(15.3m vs 11.3m)四组的中位生存期均有统计学差异(P值均<0.05)。Cox回归模型中PS评分、骨转移位置、双膦酸盐组间具统计学意义。[结论 ]PS评分、骨灶位置、双膦酸盐治疗是非小细胞肺癌骨转移预后的独立的因素。

[Objective ] To analyze the clinical features and the prognosis factors of non-small cell lung cancer with bone metastasis. [Methods] A total of 117 patients hospitalized in Liaoning Cancer Hospital with non-small cell lung cancer and bone metastasis from June 2011 to June 2014 were retrospectively analyzed,and the survival rate of 6 months, 1 year and 2 year,and the median overall survival and prognosis factors were analyzed. [Results] The mOS between PS（0-1 score） group and PS （2 scores）group （15.1m vs. 11.6m）,solitary bone lesion and muhiple bone lesion（15.7m vs. 11.9m）,axial skeleton metastasis group and limb bone metastasis group（14.9m vs. 11.2m） ,bisphosphonate and none bisphosphonate （ 15.3m vs. 1 1.3m） was significantly different（P all 〈0.05）. All the differences above mentioned have reached statistical significance. Cox regression showed that PS score, axial skeleton metastasis or limb bone metastasis, bisphosphonate were independent prognostic factors. [Conelusion] PS score ,bone tumor location ,bisphosphonate thera- py are independent prognostic factors in non-small cell lung cancer with bone metastasis.