摘要
目的探讨膝骨性关节炎(KOA)慢性疼痛患者静息状态下脑功能活动改变情况。方法采用局部一致性(ReHo)分析方法分析21例KOA患者(KOA组)和21例健康人群(HC组)静息状态下脑功能活动差异。结果与HC组相比,KOA组患者双侧额叶、顶叶、颞叶、小脑、边缘系统及静息状态默认网络分布区ReHo值广泛异常。结论慢性疼痛疾病患者的脑功能异常除了包括了疼痛信息的处理,更是一种皮层广泛参与的情绪功能异常、认知功能损害的病理状态。
Objective To study the changes of resting-state brain activity in knee osteoarthritis （ KOA ） patients with chronic pain. Methods The data of 21 K0A patients （K0A group） and 21 healthy controls （HC group） who underwent standard resting-state fMRI scan were analyzed with regional homogeneity （ReHo） method to observe the changes in the patients in contrast to the controls. Results Com- pared to HC group, patients of the K0A group showed ReHo changes in bilateral frontal lobe, bilateral parietal lobe, bilateral temporal lobe, bilateral cerebellum, limbic system and default-mode network. Conclusion Patients with chronic pain demonstrate abnormal neuron activities in the brain regions, and control loops not only related with pain but also related with emotive function disorder and cognitive impairment.
作者
石爱军
李春雷
吴媛
江开航
黄兴涛
罗甜
王静
SHI Ai-jun LI Chun-lei WU Yuan JIANG Kai-hang HUANG Xing-tao LUO Tian WANG Jing(Department of Radiology, Central Hospital of Qianjiang, Chongqing 409000, China Department of Radiology, Chinese Traditional Chinese Medicine Ortho- paedic Hospital of Chongqing, Chongqing 400012, China Department of Radiology, Fifth Peopl＇ s Hospital of Chongqing, Chongqing 400026, China Department of Ophthalmology and Otorhinolaryngology, Peopl＇ s Hospital of Nanan District, Chongqing 400060, China)
出处
《局解手术学杂志》
2017年第6期419-422,共4页
Journal of Regional Anatomy and Operative Surgery
基金
2015重庆市临床重点专科建设项目(渝卫医函[2015]517号)
关键词
膝骨性关节炎
慢性疼痛
功能磁共振
静息态
局部一致性
knee osteoarthritis
chronic pain
functional magnetic resonance
resting-state
regional homogeneity
