探讨血清促甲状腺素与甲状腺癌的发病关系

The relationship between serum thyroid stimulating hormone and thyroid cancer

目的探讨甲状腺癌的病理发病与促甲状腺激素（TSH）水平的相关性。方法选取450例2014年8月~2016年8月间我院收治的甲状腺患者作为本组研究对象,分析患者的性别、年龄、淋巴结情况、肿瘤情况、治疗前后实验室检查结果,探讨TSH水平与甲状腺癌的发病关系。结果甲状腺组患者TSH水平显著高于良性肿瘤组（P〈0.05）;TSH水平与患者病灶直径、肿瘤分期、淋巴结转移及包膜侵犯呈显著性相关关系（P〈0.05）,但TSH水平与患者年龄、性别、肿瘤数及血管侵犯无显著相关性;甲状腺癌患者高TSH水平例数显著升高（P〈0.05）。结论血清中TSH水平与甲状腺癌的发生与发展密切相关,并与患者淋巴结转移、肿瘤分期密切相关,且较高的TSH水平可增强甲状腺癌的患病风险。

Objective To investigate the correlation between the incidence of thyroid carcinoma and TSH, and to provide evidence for clinical application.MethodsSelect 450 cases of patients with thyroid from August 2014 to August 2016 in our hospital as the object of study in this group, the analysis of gender and age of patients, lymph nodes, tumor, laboratory examination results, to explore the relationship between TSH levels and thyroid cancer.ResultsThyroid patients with TSH was significantly higher than that in benign tumor group （P〈0.05）;the level of TSH and patients with lesion diameter, tumor stage, lymph node metastasis and capsule invasion was significantly correlated （P〈0.05）, but the level of TSH and age, gender, tumor number, vascular invasion and no significant correlation;TSH the level of thyroid cancer patients were significantly increased （P〈0.05）.ConclusionThe level of TSH in serum is closely related to the occurrence and development of thyroid cancer, and is closely related to lymph node metastasis and tumor stage, and the higher TSH level can increase the risk of thyroid cancer.