小儿消化不良性腹泻临床特点及联合用药效果观察

Observation on the effect of combined medicine and clinical characteristics of children with dyspepsia diarrheat

目的探讨小儿消化不良性腹泻临床特点及酪酸梭菌活菌散联合肠胃康颗粒治疗效果。方法选取2013年2月~2015年10月在桐庐县第一人民医院儿科接受治疗的76例消化不良性腹泻患儿作为研究对象,采用随机数字表法分为试验组和对照组各38例,2组患儿均给予肠胃康颗粒,试验组同时加用酪酸梭菌活菌散治疗,3 d为1个疗程,连续治疗2个疗程。结果治疗前,试验组和对照组的各项临床症状积分差异不具有统计学意义。治疗后,试验组的食欲不振、腹痛、腹泻、腹胀及大便性状积分均低于对照组,差异具有统计学意义（P〈0.05）;治疗前,试验组和对照组的血清胃动素、胃泌素、生长抑素水平差异不具有统计学意义。治疗后,试验组的血清胃动素、胃泌素水平均低于对照组、血清生长抑素水平高于对照组,差异具有统计学意义（P〈0.05）;治疗后,试验组的总有效率92.11%高于对照组73.68%,差异具有统计学意义（P〈0.05）。结论小儿消化不良性腹泻患者常表现为食欲不振、腹痛、腹泻、腹胀及大便性状。酪酸梭菌活菌散结合肠胃康颗粒治疗小儿消化不良性腹泻效果较好,值得临床推广应用。

Objective To investigate the clinical characteristics of children with dyspepsia diarrhea and the effect of Clostridium butyricum powder combined with changweikang granules on the treatment of the children with this diseases.MethodsFrom February 2013 to October 2015 in department of pediatrics, Tonglu County the First People＇s hospital, 76 cases with dyspepsia diarrhea as the research object, were randomly divided into the experimental group and the control group, 38 cases in each group.The two groups were given changweikang granules, at this basis, the observation group were given clostridium butyricum powder.3 days for a course of treatment, the two groups were treated for 2coureses continuously.ResultsBefore treatment, there were no significant differences in clinical symptom scores between the two groups.After treatment, the scores of loss of appetite, abdominal pain, diarrhea, abdominal distension and stool in the experimental group were lower than those in the control group, the difference was statistically significant （P〈0.05）;Before treatment, the serum motilin, gastrin and somatostatin levels in the two groups were not statistically significant.After treatment, the serum motilin and gastrin levels in the experimental group were lower than those in the control group, and the level of serum somatostatin was higher than that of the control group, the difference was statistically significant;After treatment, the total effective rate in the experimental group was 92.11% higher than that in the control group （73.68%）, and the difference was statistically significant （P〈0.05）.ConclusionPediatric indigestion diarrhea often showed loss of appetite, abdominal pain, diarrhea, abdominal distension and stool.The effect is good which clostridium butyricum powder combined with changweikang granules on the treatment of infantile indigestion diarrhea, it is worthy of clinical application.