宫炎平胶囊配合重组人干扰素α2b阴道泡腾片治疗宫颈人乳头瘤病毒感染的临床疗效

Clinical curative effect of Gongyanping capsule combined with recombinant human interferon α2b vaginal effervescent tablets in the treatment of human papillomavirus infection

目的观察宫炎平胶囊配合重组人干扰素α2b阴道泡腾片治疗宫颈人乳头瘤病毒感染的临床疗效。方法选取浙江省象山中医医院2014年5月~2016年5月收治的宫颈人乳头瘤病毒感染患者80例,依据治疗方法将这些患者分为宫炎平胶囊配合重组人干扰素α2b阴道泡腾片治疗组（联合治疗组,40例）和单纯宫炎平胶囊治疗组（单独治疗组,40例）2组,对2组患者的临床疗效、人乳头瘤病毒（Human papilloma virus,HPV）DNA水平、人乳头瘤病毒感染情况、不良反应发生情况进行统计分析。结果联合治疗组患者治疗的总有效率95.0%（38/40）,显著高于单独治疗组80.0%（32/40）（P〈0.05）,HPV-DNA水平显著低于单独治疗组（P〈0.05）,治疗后1个月的HPV感染阴性率2.5%（1/40）显著低于单独治疗组10.0%（4/40）（P〈0.05）,治疗后2个月、3个月的HPV感染阴性率67.5%（27/40）、97.5%（39/40）均显著高于单独治疗组40.0%（16/40）、77.5%（31/40）（P〈0.05）;2组患者的不良反应发生率12.5%（5/40）、7.5%（3/40）之间的差异无统计学意义。结论宫炎平胶囊配合重组人干扰素α2b阴道泡腾片治疗宫颈人乳头瘤病毒感染的临床疗效较单纯宫炎平胶囊治疗显著,其不会在极大程度上增加患者的不良反应,安全有效。

Objective To observe the clinical curative effect of Gong Yanping capsule combined with recombinant human interferon α2b vaginal effervescent tablets in the treatment of human papillomavirus infection.Methods80 cases of patients with cervical HPV infection in Xiangshan hospital of traditional Chinese medicine from May 2014 to May 2016 were selected, these patients were divided into Gong Yanping capsule combined with interferon treatment group （combined treatment group, 40cases） and pure Gongyanping capsule treatment group （single treatment group, 40cases） two groups according to the treatment methods, the clinical curative effects, HPV-DNA levels, HPV infection status, incidences of adverse reactions of the two groups were statistically analyzed.ResultsThe clinical total efficiency of the combined treatment group 95% （38/40） was significantly higher than the single treatment group 80% （32/40） （P〈0.05）, the HPV-DNA level was significantly lower （P〈0.05）, the HPV infection negative rate 1 months after treatment 2.5% （1/40） was significantly lower than the single treatment group 10% （4/40） （P〈0.05）, the negative rates 2 months, 3 months after treatment 67.5% （27/40）, 97.5% （39/40） were significantly higher than the single treatment group 40% （16/40）, 77.5% （31/40） （P〈0.05）;The difference of incidences of adverse reactions between the two groups 12.5% （5/40）, 7.5% （3/40） was not significant.ConclusionThe clinical curative effect of Gong Yanping capsule combined with Recombinant Human Interferon α2b Vaginal Effervescent Tablets in the treatment of human papillomavirus infection is more significant than pure Gongyanping capsule treatment, it will not increase the adverse reactions of patients in a great extent, is safe and effective.