玻璃酸钠联合糖皮质激素治疗肩周炎的疗效观察

Observation of the clinical effect of sodium hyaluronate combined with glucocorticoid on the treatment of periarthritis of shoulder

目的探讨玻璃酸钠联合糖皮质激素治疗肩周炎的效果。方法选取宁波市第二医院骨科2014年5月~2016年3月收治的肩周炎病例患者106例,按随机数字表法分为对照组和研究组,分别53例。对照组予以消炎、镇痛治疗;研究组在消炎、镇痛的基础上予以玻璃酸钠联合糖皮质激素治疗,5周为1个疗程。比较2组患者血清炎症及实验室相关指标。结果与治疗前比较,2组治疗后肩关节活动度升高,VAS评分降低,肩关节力量、运动范围、日常活动升高,血清IL-6、IL-10、TNF-α水平降低（P〈0.05）;与对照组比较,研究组治疗后肩关节活动度较高,VAS评分较低,肩关节力量、运动范围、日常活动较高,血清IL-6、IL-10、TNF-α水平较低（P〈0.05）;对照组有效率73.59%,研究组有效率90.57%,研究组有效率显著高于对照组,但统计学无差异。结论玻璃酸钠联合糖皮质激素治疗肩周炎疗效确切,降低炎症指标,提高关节活动度。

Objective To investigate the clinical effect of sodium hyaluronate combined with glucocorticoid on the treatment of periarthritis of shoulder.Methods106 patients in department of orthopedics, the second hospital of Ningbo with periarthritis of shoulder were randomly divided into 2 groups （n=53）.The control group were treated with anti-inflammatory and analgesic treatment, at this basis, the study group were treated with sodium hyaluronate combined with Glucocorticoid.5 weeks for a course of treatment.Levels of serum inflammation, laboratory-related indicators were compared.ResultsCompared with before treatment, shoulder joint activity in the two groups increased, VAS score decreased, the scores of strength of shoulder joint, range of motion and daily activities increased, levels of serum IL-6, IL-10, TNF-α decreased（P〈0.05）.Compared with the control group, scores of activity in the study group were higher, VAS scores were lower, scores of strength of shoulder joint, range of motion and daily activities were higher, levels of serum IL-6, IL-10, TNF-α were lower（P〈0.05）.The effective rate in the control group（73.59%） was lower than the study group（90.57%）, but there was no statistical difference.ConclusionThe effect is accurate which sodium hyaluronate combined with glucocorticoid was used in the treatment of periarthritis of shoulder, and it can reduce the inflammation index and improve the joint activity.