血塞通与丹红注射液联合用药对急性脑梗死患者的疗效及血清胆红素与尿酸水平影响的比较研究

Effects of Xuesaitong and Danhong injection on acute cerebral infarction and the effects of serum bilirubin and uric acid

目的探究血塞通与丹红注射液联合用药对急性脑梗死患者的疗效及血清胆红素与尿酸水平影响的比较研究。方法收集湖州市第一人民医院神经内科收治的急性脑梗死患者68例,根据治疗方法不同分为对照组和试验组,其中试验组34例,对照组34例,2组均实施常规治疗方案,对照组给予血塞通注射液400 mg＋5%葡萄糖注射液250 m L静脉点滴,每天1次;试验组给予丹红注射液40 m L＋5%葡萄糖注射液250 m L静脉点滴,每天1次。2组患者一个周期均为7 d,共治疗2个周期。治疗结束后对比分析2组患者临床疗效、血尿酸、胆红素、血同型半胱氨酸、超敏C反应蛋、血清胱抑素C以及不良反应。结果治疗后与对照组相比,试验组临床总有效率较高（P〈0.05）。与对照组相比,试验组血尿酸、血同型半胱氨酸、超敏C反应蛋、血清胱抑素C水平较低（P〈0.05）,胆红素水平较高（P〈0.05）。2组不良反应比较,差异无统计学意义。结论丹红注射液对急性脑梗死的临床疗效显著,下调血尿酸水平,上调胆红素水平,改善内皮细胞受损程度,保护脑神经组织。

Objective To investigate the comparison of blood uric acid and bilirubin levels on patients with acute cerebral infarction and the clinical curative effect of Donhong injection.MethodsA total of 68 patients with acute cerebral infarction from our hospital neurology, according to different therapeutic methods were divided into control group and experimental group with 34 cases in each group, two groups were treated by conventional treatment, patients in the control group were treated by blood flux injection 400 mg＋5% glucose injection 250 mL intravenous drip, once a day;patients in the experimental group were treated by Dan red injection 40 mL＋5% glucose injection 250 mL intravenous drip, once a day,2 groups of patients were treated for 2 cycles,a cycle with 7 d.Compared the clinical efficacy, blood uric acid, bilirubin, blood homocysteine, hyperensitive C-reactive protein, serum inhibition C and adverse reactions in the two groups after treatment.ResultsCompared with the control group, the experimental group clinical total effective rate was higher after treatment （P〈 0.05）.Compared with the control group, the experimental group blood uric acid, blood homocysteine, hypersensitive C-reactive protein, serum inhibition C levels were lower （P〈 0.05）, bilirubin level was higher（P〈 0.05）.Adverse reactions compared between the two groups, there was no statistically significant difference.ConclusionDonhong injection in the treatment of acute cerebral infarction clinical curative effect is distinct, dacrease blood uric acid level and increase bilirubin level, improve endothelial cell damage, protect the brain tissue.