醒脑静注射液配合高压氧对脑卒中偏瘫患者远期临床及康复效果的观察

Long-term clinical and rehabilitation effect of Xingnaojing injection with hyperbaric oxygen in the stroke patients

目的观察醒脑静注射液配合高压氧对脑卒中偏瘫患者远期临床及康复效果。方法选择2012年5月~2014年4月在宁夏医科大学附属吴忠市人民医院接受治疗的脑卒中偏瘫患者100例。按照随机数字法将本次研究对象分为试验组（50例）和对照组（50例）。给予所有患者进行常规治疗,每天阿司匹林0.5 g,尼莫地平每天3次口服治疗,对照组患者在此基础上联合20 m L醒脑静注射液进行治疗,每天1次。试验组在对照组的基础上联合使用高压氧进行治疗,每天1 h。均治疗2个月后出院,在治疗后的18个月对2组患者进行回访,比较2组患者治疗前后行动能力、日常生活能力、生活质量以及继发性损伤,并对患者的神经功能缺损进行评估。结果在治疗后18个月,试验组患者的独立行走率为68%,明显高于对照组的42%（P〈0.05）,治疗后试验组患者的神经功能缺损评估为（10.43±2.19）分,改善效果显著优于对照组的（16.04±3.23）分,试验组患者的日常生活能力、生活质量以及继发性损伤改善效果显著优于对照组,差异有统计学意义（P〈0.05）。结论醒脑静注射液联合高压氧治疗脑卒中偏瘫患者,能够改善患者的日常生活能力以及生活质量,利于患者康复,其远期的临床效果显著,不良反应小。

Objective To observe long-term clinical and rehabilitation effect of Xingnaojing injection with hyperbaric oxygen on the stroke patients with hemiplegia.Methods100 patients with cerebral apoplexy hemiplegia from May 2012 to April 2014 in Wuzhong City People＇s Hospital Affiliated to Ningxia Medical University during the period.According to the stochastic indicator method, the object of this study were divided into experimental group （50 cases） and control group （50 cases）.For all patients with conventional treatment, daily aspirin 0.5 g, nim horizon each time, three times a day oral treatment, control group patients on the basis of the joint 20 mL Xingnaojing injection, once a day.Patients in the experimental group were given hyperbaric oxygen treatment on the basis of the combination, for an hour every day.Treatment for 2 months after hospital discharge, 18 months after treatment to return of two groups of patients, compared two groups of patients before and after treatment action, ability of daily life, the quality of life as well as the secondary injury, and the patient＇s neurologic deficits were evaluated.ResultsIn 18 months after treatment, the treatment group patients walk rate was 68%, significantly higher than that of control group 42%（P〈0.05）, nerve function defect assessment in experimental group patients was （10.43±2.19） scores,was significantly better than control group （16.04±3.23） scores, daily life ability, life quality and improve secondary injury effect in experimental group was significantly better than control group, difference has statistical significance （P〈0.05）.ConclusionXingnaojing injection combined hyperbaric oxygen treatment of stroke patients with hemiplegia, can improve long-termdaily life skills, and improve quality of life with rehabilitation, the long-term clinical effect is remarkable, less adverse reaction.