参蛭活血胶囊对高血压脑出血硬通道穿刺引流术后的影响

Effect of Shenzhi HuoXue capsule on hard channel puncture drainage in patients with hypertensive intracerebral hemorrhage

目的分析高血压脑出血硬通道穿刺引流术后应用参蛭活血胶囊辅助治疗对患者预后的影响。方法按随机数字表法将山东省泰安军分区第一干休所2013年5月~2015年4月期间收治的行高血压脑出血硬通道穿刺引流术的患者106例分为2组（各53例）。观察组在术后给予参蛭活血胶囊辅助治疗,对照组不服用参蛭活血胶囊,2组患者在基础治疗上保持一致。观察2组患者治疗期间主要并发症发生情况、住院期间病死人数和治疗后残疾人数、治疗前后格拉斯哥预后评分（GOS评分）和日常生活活动能力量表指数（BI指数）、斯堪的那维亚卒中量表评分（SSS评分）和神经行为认知状况测试评分（NCSE评分）的变化。结果 （治疗期间观察组患者的感染、肝及肾功能异常和再出血发生比例均低于对照组,且观察组感染的比例和对照组相比（28.30%比49.06%）,差异具有统计学意义（P〈0.05）。（住院期间观察组病死比例为18.87%,低于对照组26.42%,但差异无统计学意义;观察组治疗后致残比例为26.42%,显著低于对照组45.28%,差异具有统计学意义（P〈0.05）。治疗后2组患者的GOS和BI指数均高于治疗前（P〈0.05）;观察组治疗后GOS和BI指数分别为（12.85±0.81、83.95±4.37）分,均高于对照组（10.05±0.73、74.95±4.06）分,且差异均具有统计学意义（P〈0.05）。治疗后2组患者的SSS和NCSE评分均高于治疗前（P〈0.05）;观察组治疗后SSS和NCSE评分分别为（47.10±4.18、66.72±3.99）分,均高于对照组（38.42±3.05、59.34±3.45）分,且差异均具有统计学意义（P〈0.05）。结论在高血压脑出血硬通道穿刺引流术后应用参蛭活血胶囊可减少患者致残率,促进患者生活自理能力和认知能力恢复。

Objective To observe the influences of Shenzhi Huoxue capsule to prognosis of patients with hypertensive intracerebral hemorrhage after hard channel puncture and drainage.MethodsTo divide 106 patients with hypertensive intracerebral hemorrhage from May 2013 to April 2015 into two groups.The observation group with 53 cases received Shenzhi Huoxue capsule after hard channel puncture and drainage, the control group did not receive Shenzhi Huoxue capsule.To observe the complications rate, the number of deaths during hospitalization, the number of persons with disabilities after treatment, GOS score, BI index, SSS score and NCSE score of two groups.Results（During treatment, the infection, liver and renal dysfunction and rebleeding rates of observation group were lower than control group, and the infection ratio was significant （P〈0.05）.（During treatment, the proportion of deaths of observation group was 18.87%,lower than control group with 26.42%, but the differences were not statistically significant.The proportion of disabilities of observation group was 26.42%,lower than control group with 45.28%, and the differences were statistically significant （P〈0.05）.After treatment, GOS score and BI index of two groups were higher than before treatment（P〈0.05）.GOS score and BI index of the observation group were （12.85±0.81,83.95±4.37）score, higher than the control group with （10.05±0.73,74.95±4.06）score, and the differences all were statistically significant （P〈0.05）.After treatment, the SSS score and NCSE score of two groups were higher than before treatment（P〈0.05）,the SSS score and NCSE score of observation group were （47.10±4.18,66.72±3.99）score, higher than the control group with （38.42±3.05,59.34±3.45）score, and the differences were statistically significant （P〈0.05）.ConclusionAdding Shenzhi Huoxue capsule to patients with hypertensive intracerebral hemorrhage after hard channel puncture and drainage can reduce the number of persons with disabilities and improve life self-care ability and cognitive ability.