八珍颗粒治疗风湿性多肌痛患者的效果及对免疫水平的影响

Study on the effect of Bazhen granules on the treatment of patients with polymyalgia rheumatica and effect on immune level

目的探讨中药八珍颗粒结合常规治疗对风湿性多肌痛患者的治疗的效果及对患者免疫水平的影响。方法选取2013年12月~2016年5月山东大学第二医院收集的80例风湿性多肌痛患者采用随机数字表法分为八珍颗粒组和常规组各40例,2组均基础性给予泼尼松治疗,八珍颗粒组加用八珍颗粒治疗,连续治疗3个月。结果治疗前,八珍颗粒组和常规组的血清ESR、CRP水平差异不具有统计学意义;治疗后,八珍颗粒组的血清ESR、CRP水平低于常规组,差异具有统计学意义（P〈0.05）;治疗后,八珍颗粒组的血清CD3~＋、CD4~＋、CD4~＋/CD8~＋、IgG、Ig M、Ig A水平高于常规组（P〈0.05）,CD8~＋水平低于常规组（P〈0.05）,八珍颗粒组的愈显率85.00%高于常规组的62.50%（P〈0.05）,八珍颗粒组的总有效率95.00%高于常规组的87.50%,但差异不具有统计学意义。结论中药八珍颗粒结合常规治疗对风湿性多肌痛患者效果较好,同时改善患者的免疫水平。

Objective To investigate the effect of Bazhen granules combined with conventional treatment in patients with polymyalgia rheumatica and effect on immune level.MethodsFrom December 2013 to May 2016 in the second hospital of Shandong University 80 cases with polymyalgia rheumatica were randomly divided into the Banzhen granule group and the conventional group, 40 cases in each group.The two groups were given basic treatment with prednisone.The Bazhen granules group were given Bazhen granules at the same time.The two group were given continuous treatment for 3 months.ResultsBefore treatment, the difference of serum ESR and CRP levels between the Bazhen granules group and the normal group was not statistically significant.After treatment, in the Bazhen granule group, serum ESR, CRP levels were lower than those in the conventional group, the difference was statistically significant （P〈0.05）;serum CD3＋, CD4＋, CD4＋/CD8＋, IgG, IgM, IgA levels were higher than those in the conventional group （P〈0.05）, CD8＋ level was lower than that in the conventional group （P〈0.05）.The effective rate in the Bazhen granule group 85%was higher than that in the conventional group 62.50% （P〈0.05）.The total effect rate in the Bazhen granule group95% was higher than that in the conventional group 87.50%, but the difference was not statistically significant.ConclusionThe effect is better that Bazhen granules combined with conventional treatment on the treatment of patients with polymyalgia rheumatica, which can improve the patient＇s immune level.