丹参川芎嗪注射液辅助治疗高血压脑出血患者的临床效果

Clinical effect of salvia Ligustrazine injection in the treatment of hypertensive intracerebral hemorrhage

目的探讨丹参川芎嗪注射液辅助治疗高血压脑出血患者的临床效果。方法选取2013年2月~2016年5月本院收治的118例高血压脑出血患者,采用抽签方法随机分为丹参川芎嗪组、常规组,各59例。2组患者均于术后采用相同的基础治疗措施,丹参川芎嗪组同时给予丹参川芎嗪注射液,对比两组治疗后的临床效果、神经缺损功能恢复情况。结果治疗14d后,丹参川芎嗪组患者的格拉斯哥昏迷评分（Glasgow Coma Scale,GCS）评分、神经功能缺损评分、血清C反应蛋白（C reactive protein,CRP）、内皮素1水平均低于常规组,差异有统计学意义（P〈0.05）,丹参川芎嗪组患者的0级脑水肿8例（13.56%）、1级脑水肿49例（83.05%）、2级脑水肿2例（3.39%）,常规组0级脑水肿3例（5.09%）、1级脑水肿47例（79.66%）、2级脑水肿9例（15.25%）,差异有统计学意义（P〈0.05）;治疗3个月后,丹参川芎嗪组患者的预后良好49例（83.05%）,常规组预后良好39例（66.10%）,差异有统计学意义（P〈0.05）。结论丹参川芎嗪注射液辅助治疗高血压脑出血患者有利于尽快缓解患者的脑水肿、促进神经功能恢复,对患者远期恢复有利。

Objective To investigate the clinical effect of Salvia Ligustrazine Injection in the treatment of hypertensive intracerebral hemorrhage.MethodsFrom February 2013 to May 2016, 118 patients with hypertensive intracerebral hemorrhage admitted in our hospital were randomly divided into Danshen ligustrazine group, conventional group and 59 cases.2 groups of patients were treated with the same basic treatment after surgery, Salvia Ligustrazine group also received Danshen ligustrazine injection, compared the two groups after treatment of clinical effects, nerve defect function recovery.ResultsAfter 14 days of treatment, the Glasgow Coma Scale （GCS） GCS score, neurological deficit score, C reactive protein （CRP） and ET-endothelin-1 were lower in the Salvia Ligustrazine group （13.56%）, brain edema in grade 1 （83.05%）, 2 cases of brain edema in grade 2 （3.39%）, and 9 cases of cerebral edema in grade 2 （79.66%）, 9 cases （15.25%） in grade 2 brain edema, the difference was statistically significant （P〈0.05）, and the treatment group was significantly higher than that in the control group After 3 months, the prognosis of patients with Salvia miltiorrhiza was good （49.05%）, and the prognosis was good in 39 cases （66.10%）, the difference was statistically significant （P〈0.05）.ConclusionSalvia Ligustrazine Injection is an effective method for the treatment of hypertensive intracerebral hemorrhage in patients with cerebral edema as soon as possible.It can promote the recovery of neurological function and benefit the patients＇ long-term recovery.