盐酸羟考酮静脉自控镇痛泵用于宫颈癌根治术后疼痛的临床观察

Clinical observation of radical postoperative pain oxycodone controlled intravenous analgesia for the treatment of cervical cancer

目的观察盐酸羟考酮静脉自控镇痛泵（patient-controlled-intravenous analgesia,PCIA）用于宫颈癌根治术后患者镇痛的效果与不良反应。方法选取2016年3月~2017年2月浙江省肿瘤医院择期行经腹宫颈癌根治术患者108例,采用随机法分为观察组（54例）与对照组（54例）,观察组给予盐酸羟考酮注射液静脉自控镇痛泵镇痛,对照组患者给予枸橼酸舒芬太尼注射液自控镇痛泵镇痛,对比2组患者术后肛门排气时间、药物不良反应以及术后6、12、24、48h的NRS（numeric rating scale,NRS）疼痛评分。结果疼痛评分：12 h时段观察组对比对照组NRS疼痛评分差异具有统计学意义（P〈0.05）;6、24、48 h时段2组NRS疼痛评分差异均无统计学意义。不良反应：对照组不良反应总发生率（34.54%）明显高于观察组（16.36%）,差异有统计学意义（P〈0.05）。排气时间：观察组（2.93±0.63）d,对照组（2.76±0.61）d,差异无统计学意义。结论盐酸羟考酮静脉自控镇痛泵镇痛对于经腹宫颈癌根治术患者术后镇痛效果良好,不良反应少。

Objective To observe the curative resection of oxycodone hydrochloride controlled intravenous analgesia pump after treatment of cervical cancer （patient-controlled-intravenous analgesia, PCIA） and the adverse effect of pain.Methods March 2016 to February 2017 undergoing open radical resection of cervical cancer patients with 108 cases, were randomly divided into observation group（n=54） and control group（n=54）, the observation group was given oxycodone hydrochloride injection intravenous patient-controlled analgesia pump, the control group were treated with Sufentanil Citrate Injection patient-controlled analgesia pump, anal exhaust time, contrast two groups of patients with adverse drug reactions and postoperative 6h, 12h, 24h, 48h （NRS Numeric Rating Scale, NRS） pain score.ResultsPain score： 12h observation group compared with the control group NRS pain score （P〈0.05）, with statistical difference, 6h, 24h, 48h time group NRS pain scores haveno statistical difference.Adverse reactions： in the observation group, 7 cases of nausea, vomiting in 6 cases, 2 cases of hypotension;control group 16 cases of nausea and vomiting in 14 cases, 1 cases of hypotension, 1 cases of skin allergy, 1 cases of dizziness, adverse reaction rates were significantly higher than the observation group （P〈0.05）, the difference was statistically significant.Exhaust time： observation group （2.93±0.63） days, the control group （2.76±0.61） days, no statistical significance.ConclusionOxycodone controlled intravenous analgesia pump for analgesia in patients with radical resection of cervical carcinoma after open surgery, with less adverse reactions.