丁胺卡那霉素和左氧氟沙星方案治疗复治肺结核患者的近期疗效及安全性分析

Short term efficacy and safety analysis of amikacin and levofloxacin regimen in treatment of patients with retreatment pulmonary tuberculosis

目的探索丁胺卡那霉素和左氧氟沙星方案治疗复治肺结核患者的近期疗效及安全性。方法选取2015年5月至2016年5月期间我院收治的100例复治肺结核患者,将患者动态随机化分为两组,两组患者各有50例,对照组和观察组分别采用正规复治抗痨方案(HRZE)和加用丁胺卡那霉素和左氧氟沙星方案治疗。结果观察组和对照组两组患者,对比治疗总有效率、总不良事件发生率、各时间段的转阴情况均存在差异性(P<0.05)。结论丁胺卡那霉素和左氧氟沙星方案治疗复治肺结核患者效果显著,且安全性较高。

Objective To explore the short tema efficacy and safety analysis of amikacin and levofloxacin regimen in treatment of patients with retreatment pulmonary tuberculosis. Methods 100 eases of patients with retreatment pulmonary tuberculosis treated in our hospital from May 2015 to May 2016 were selected, the patients were randomly divided into two groups, eaeh group with 50 patients, control group treated with normal retreatment chemotherapy regimen （HRZE） and observation group treated with amikaein and levofloxacin regimen. Results The total effective rate, the incidence rate of adverse events, and the negative situation of each period were different between the observation group and the control group （P 〈 0. 05 ）. Conclusions Amikaein and levofloxacin regimen for retreatment TB is remarkably effective and highly safe.