阿尔茨海默病患者脑萎缩与认知功能障碍的相关性

Correlation between Brain Atrophy and Cognitive Impairment in Patients with Alzheimer

目的分析阿尔茨海默病患者脑萎缩与认知功能障碍的相关性。方法选取近些年来接受治疗的阿尔茨海默病患者45例作为观察组,并选取同期非阿尔茨海默病患者45例作为对照组,分析阿尔茨海默病患者脑萎缩与认知功能障碍的关系。结果观察组侧脑室颞角间径、三脑室宽度、侧裂池宽平均宽度、侧脑室前角宽度、四叠体池宽度、侧脑室体部平均宽度、脑沟平均宽度、侧脑室枕部平均宽度明显高于对照组,患者记忆力、定向力、解决问题能力、社会功能、家庭生活、自护能力障碍程度明显高于对照组,差异具有统计学意义(P<0.05)。结论脑萎缩是导致阿尔茨海默病患者的特异性标志,会造成患者认知功能障碍。

Objective To analyze the correlation between brain atrophy and cognitive impairment in patients with Alzheimer. Methods 45 cases of Alzheimer in recent years in our hospital were selected as the observation group, and 45 patients without Alzheimer in the same period in our hospital as control group. The relationship between brain atrophy and cognitive impairment in patients with Alzheimer was analyzed. Results The width of temporal and anterior horn of lateral ventricle,three ventricle,quadrigeminal and the average width of lateral fissure, the body and occipital lateral cerebral ven-tricle and sulci in the observation group were significantly bigger than that in the control group. The memory, orientation, problem solving ability, social function, family life, the degree of self - care ability impairment of the observation group were significantly higher than that of the control group （ P 〈 0. 05 ） . Conclusion Brain atrophy is a specific marker of Alzheimer, which may lead to cognitive impairment.