红花黄色素对不稳定型心绞痛病人PCI术后心肌损伤的影响

Effects of Safflor Yellow on Incidence of Myonecrosis in Patients with Unstable Angina after Percutaneous Coronary Intervention

目的研究红花黄色素对不稳定型心绞痛病人经皮冠状动脉介入治疗(PCI)后心肌损伤的影响。方法选取60例不稳定型心绞痛病人,随机分为常规西药治疗组(对照组)和红花黄色素联合西药治疗组(治疗组),观察两组病人用药前后血小板P-选择素的变化及介入治疗前后心肌损伤标记物的水平。结果治疗后,治疗组血小板P-选择素水平低于对照组(P<0.05);介入治疗后心肌损伤发生率,对照组高于治疗组(P<0.05);治疗组PCI术后CK-MB、TnI水平较对照组明显降低(P<0.05)。结论介入治疗前给予红花黄色素能够有效抑制血小板的激活,降低PCI术后心肌损伤的发生。

Objective To observe the effect of safflor yellow(SY) on myonecrosis in unstable angina(UA) patients undergoing percutaneous coronary intervention(PCI).Methods Sixty patients with UA undergoing stent implantation were randomized into two groups:control group treated with routine treatment,and treatment group treated with SY and routine treatment.P-selecting level was observed before and after treatment.The incidence of myonecrosis was evaluated by the levels of creatine kinase-myocardial band(CK-MB) and troponin I(TnI) before and after PCI.Results P-selectin level in treatment group was lower than that in control group(P <0.05).The incidence of CK-MB and TnI elevation in treatment group were lower than that in control group(P <0.05).Conclusion SY displays its effect on decreases the risk of myonecrosis following PCI in UA patients,which may related to suppress the activation and assembly of platelets.