急性等容血液稀释联合回收式自体输血在异位妊娠手术患者中的应用研究

Application of acute normovolemic hemodilution combined with salvaged autotransfusion in surgical patients with ectopic pregnancy

目的探讨急性等容血液稀释(ANH)联合回收式自体输血在异位妊娠手术患者中的应用价值。方法选择2015年3月至2016年4月本院收治的异位妊娠大出血手术患者85例。46例患者接受ANH联合自体血回输治疗(观察组),39例患者接受异体血输注治疗(对照组)。收集两组患者年龄、体质量指数(BMI)、术前血红蛋白(Hb)水平、腹痛时间、停经时间等基线数据。记录两组患者术中失血量及输血量。检测两组患者术前及术后白细胞(WBC)、C-反应蛋白(CRP)及红细胞沉降率(ESR)水平。结果两组患者年龄、BMI、术前Hb水平、腹痛时间、停经时间等基线资料比较差异无统计学意义(P>0.05)。观察组患者术前预存血量(559±128)mL、回收血量(510±103)mL,库存血输注例数和输注量明显少于对照组(P<0.05)。两组患者术前CRP、ESR及WBC水平比较差异无统计学意义(P>0.05),术后第1、3、5天CRP、ESR水平及术后第1、3天WBC水平均高于术前(P<0.05)。观察组术后第1、3、5天CRP、ESR水平均明显低于对照组(P<0.05)。结论与输注异体血相比,ANH联合回收式自体输血可降低异位妊娠患者术后炎性反应程度,具有一定的临床应用价值。

Objective To explore the application value of acute normovolemic hemodilution(ANH)combined with salvaged autotransfusion in surgical patients with ectopic pregnancy.Methods From Mar.2015 to Apr.2016,46 surgical patients with ectopic pregnancy,receiving ANH combined with salvaged autotransfusion,were enrolled as observation group,and 39 surgical patients with ectopic pregnancy,receiving allogeneic blood transfusion were enrolled as control group.The baseline data,including age,body mass index(BMI),preoperative hemoglobin(Hb),abdominal pain time and menopause time were collected.The amounts of blood loss and blood transfusion were recorded.Preoperative and postoperative levels of white blood cells(WBC),C-reaction group(CRP)and erythrocyte sedimentation rate(ESR)were detected.Results The baseline data,including age,BMI,preoperative Hb,abdominal pain time and menopause time of the two groups were without statistical difference(P>0.05).The preoperative preexisting blood volume was(559±128)mL and the intraoperative blood collection was(510±103)mL in observation group.The cases and volume of banked blood infusion in observation group were lower than those in control group(P<0.05).Preoperative levels of CRP,ESR and WBC of the two groups were not statistical different(P>0.05).The levels of CRP and ESR at the postoperative 1st,3rd and5 th day and WBC levels at the postoperative 1st and 3rd day were higher than those before operation in the two groups(P<0.05).The levels of CRP and ESR at the postoperative 1st,3rd and 5th day in observation group were significantly lower than those in control group(P<0.05).Conclusion(Department of Gynaecology,the Fourth People′s Hospital of Langfang City,Langfang,Hebei 065700,China)