摘要
线粒体是细胞内重要的细胞器,在肿瘤的发生、发展中起着重要的作用。将抗癌药物靶向线粒体可以有效提高药物治疗效果,降低对正常组织的毒副作用。本文从线粒体膜电位、线粒体外膜通透性和线粒体膜转位酶3个方面,综述线粒体靶向制剂在肿瘤治疗中的研究进展,为线粒体靶向治疗系统的构建提供参考。
Mitochondrion is an important organelle in cells and plays a crucial role in tumor development. Therefore, improvement of the targeting ability of anticancer drugs to mitochondria will increase the treatment efficacy for tumor and reduce the side effect on normal tissues. Here, research progresses in mitochondrial targeting have been reviewed in three aspects for tumors treatment: the potential, permeability and translocase of mitochondrial membrane. The review provides a reference for the development of mitochondria targeted therapeutic systems.
出处
《药学学报》
CAS
CSCD
北大核心
2017年第6期879-887,共9页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(31470916,31500769)
药物质量与安全预警教育部重点实验室开放课题资助项目(DQCP2015MS01)
关键词
肿瘤
线粒体
靶向
线粒体膜电位
正电性制剂
线粒体外膜通透性
BCL-2蛋白
neoplasms
mitochondria
targeting
mitochondrial membrane potential
mitochondrial outer membrane permeabilization
preparation with positive charge
Bcl-2 protein