鹤庆产黄玛咖抗骨质疏松活性部位的化学成分研究

Studies on the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp. produced in Heqing

对云南鹤庆产黄玛咖(Lepidium meyenii Walp.)的抗骨质疏松部位进行了化学成分研究。采用MCI大孔吸附树脂、正相硅胶色谱、反相硅胶色谱、Sephadex LH-20色谱、半制备HPLC柱色谱以及重结晶等多种分离手段,从黄玛咖的正丁醇部位分离得到7个化合物,对所得单体化合物依据理化性质及波谱数据进行结构鉴定,分别为:macaolidine(1)、色氨酸(2)、胡萝卜苷(3)、(3S)-1,2,3,4-四氢-β-卡波林-3-羧酸(4)、绿原酸(5)、木犀草素(6)和金丝桃苷(7)。化合物1为一个新的酰胺类生物碱,化合物4~7均为首次从该植物中分离得到。

This study was designed to investigate the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp. （maca） produced in Heqing, Yunnan. Seven compounds were isolated from the n-BuOH extract of maca using combination of column chromatographies on MCI resin, silica gel, C 18 bonded silica gel, and Sephadex LH-20, followed by semi-preparative HPLC and recrystallization. The purified compounds were identified on the basis of their physicochemical properties and spectral data as macaolidine （1）, tryptophan （2）, daucosterol （3）, （3S）-1,2,3,4-tetrahydro-β-carboline-3-carboxylicacid （4）, chlorogenic acid （5）, luteolin （6）, and hyperoside （7）. Compound 1 is a new phenylacetamide alkaloid, and compounds 4-7 were isolated from Lepidium meyenii for the first time.