固体碱催化Knoevenagel法合成阿魏酸的工艺研究

Synthesis of Ferulic Acid by Knoevenagel Method with Solid Base

以香兰素和丙二酸为原料、苯为带水剂、固体碱为催化剂、吡啶为助催化剂,经Knoevenagel反应合成了阿魏酸,经重结晶提纯得到目标化合物,并对化合物进行了结构验证。结果表明,当n(香兰素)∶n(丙二酸)=1∶1.15、吡啶用量为5 wt%香兰素、固体碱催化剂用量为3 wt%香兰素时,反应效果最佳,阿魏酸的收率可达90%以上。

In this work,ferulic acid was synthesized by Knoevenagel reaction, in which vanillin and malonic acid, benzene, solid base and pyridine were used as starting materials,water-carrying agent, catalyst and co-catalyst, respectively. The product was pu- rified by recrystallization,then the structure was confirmed. The optimal reaction conditions were as follows molar ratio of vanillin tomalonic acid was 1：1.15 ,the mass rations of pyridine and solid base in vanillin were 5 wt% and 3 wt% ,respectively. The yield of ferulic acid could reach above 90% by using the optimal reaction condition.