封闭负压引流技术在创面愈合中的应用及机制研究进展

Advances in the research of application of vacuum-assisted closure in wound healing and its mechanism

封闭负压引流（VAC）技术是1997年美国外科医师提出的一种治疗难愈性创面的方法。因其有着快速封闭创面、控制感染、促进创面肉芽组织生长等诸多功能，经过国内外无数研究者的应用与改进，现已广泛应用于各种急、慢性创面的治疗，并取得了显著疗效。

As a new generation of negative pressure drainage technology, vacuum-assisted closure （VAC） can pro- vide stable and persistent negative pressure, and there are sever- al modes to choose from. VAC plays an important role in closing wounds quickly, controlling infection, promoting angiogenesis, increasing blood flow, and promoting granulation tissue growth of wounds. It is now widely applied in all kinds of acute, chronic, and special wounds in clinic with good therapeutic results. How- ever, we need to pay attention to contraindications and complica- tions of VAC when it is used, avoiding secondary damage due to improper treatment. In this review, we summarize VAC dress- ings, treating pressure and mode choice, mechanism in promo- ting wound healing, and clinical application of VAC.