穴位贴敷联合甲巯咪唑治疗甲状腺功能亢进的临床疗效及作用机制

Clinical effect of acupoint application combined with thiamazole in treating hyperthyroidism and its mechanism

目的观察穴位贴敷联合甲巯咪唑治疗甲状腺功能亢进(甲亢)的临床疗效与安全性,分析其作用机制。方法选取2015年10月至2016年5月接受治疗的甲亢患者100例作为研究对象,按照随机数字表法分为观察组(50例)及对照组(50例)。对照组患者接受甲巯咪唑治疗,观察组患者接受穴位贴敷联合甲巯咪唑治疗,均以2个月为1个疗程。评价两组患者治疗2个月后的临床疗效,检测血清甲状腺功能指标,并观察不良反应情况。结果治疗2个月后,观察组患者的临床痊愈率、显效率和总有效率均明显高于对照组,差异有统计学意义(P<0.05);两组患者的甲状腺功能相关指标均有显著改善,且观察组患者的改善程度优于对照组,差异均有统计学意义(P<0.05);两组患者治疗期间均未出现明显不良反应。结论穴位贴敷联合甲巯咪唑治疗甲亢临床效果确切,用药安全,值得临床推广应用和深入研究。

Objective To observe the clinical effect and security of acupoint application combined with thiamazole in treating hy- perthyroidism and to investigate its mechanism. Methods One hundred patients with hyperthyroidism in our hospital from Oct. 2015 to May 2016 were selected as the study subjects and divided into the observation group （n= 50） and control group（n= 50） according to the random number table. The control group received methimazole treatment for two months and the observation group received the acupoint application combined with thiamazole treatment for two months. The clinical effects after 2-month treatment were observed,and the serum thyroid function indicators were detected. The adverse reactions were also observed. Results The clinical cure rate, markedly effective rate and the total effective rate after treatment in the observation group were higher than those in the control group,the difference was statistically significant（P-0.05）; serum thyroid function related indicator after treatment in the two groups were improved,moreover the improvement degree in the observation group was superior to that in the control group,the differences were statistically significant（P〈0.05）. There was no obvious adverse reaction during the treatment process in all the patients of the two groups. Conclusion The effect of acupoint application combined with thiamazole in treating hyperthy- roidism is definite and safe, which is worthy of further research and clinical promotion and application.