宁夏地区1879例内分泌相关疾病患者血中维生素D水平分析

Analysis of serum vitamin D level in 1879 cases of endocrine related diseases in Yinchuan area

目的分析和了解宁夏地区内分泌相关疾病患者血中维生素D(VitD)水平的现状,为合理补充VitD及预防疾病的发生和治疗提供依据。方法收集2012年1月至2014年1月内分泌门诊及住院患者1 879例,健康者1 774例,采用罗氏公司E601电化学发光检测仪检测25-OH VitD水平,对25-OH VitD检测结果进行分析。结果 1 879例患者血清25-OH VitD水平中位数为12.47ng/mL,严重缺乏者占46.78%,缺乏和不足者占50.19%,充足者仅占3.03%。而1 774例健康者25-OH VitD水平中位数为16.44ng/mL,明显高于患者平均水平,差异有统计学意义(P<0.05)。男性患者血清25-OH VitD水平比女性高,差异有统计学意义(P<0.01)。随着年龄增长,男性和女性患者血清25-OH VitD水平有下降趋势,呈负相关关系。冬春季25-OH VitD水平明显低于夏秋季,糖尿病、高血压及甲状腺功能减退患者血清25-OH VitD缺乏程度较重,甲状腺功能亢进症和骨质疏松患者较轻。结论宁夏地区内分泌患者普遍存在VitD缺乏,需要重视及积极治疗。

Objective To analyze and understand the status quo of vitamin D（VitD） level in the patients with endocrine related disease in Yinchuan area of Ningxia to provide the basis for rational supplement of vitamin D and prevention and treatment of dis- ease. Methods A total of 1 879 inpatients and outpatients and 1 774 healthy persons in the endocrinology department of our hospital from January 2012 to January 2014 were collected. Serum 25-OH VitD level was determined by the Roche E601 electrochemilu- minescence detector. The detection results were retrospectively analyzed. Results The median of serum 25-OH VitD in 1 879 patients was 12.47 ng/mL,severe deficiency only accounted for 46.78% ,deficiency and insufficiency accounted for 50.19% and suffi- ciency was 3. 03%. But the median of 25-OH VitD in 1774 normal healthy persons was 16.44 ng/mL,which was significantly high- er than the average level in the patients,the difference was statistically significant （P〈0.05）. The serum 25-OH VitD level in male patients was higher than that in the female patients,and the difference was statistically significant （P〈0.01）. With age increase, the serum 25-OH VitD level in female and male patients revealed the decline trend, showing the negative correlation. The 25-OH VitD level in winter and spring was significantly lower than that in summer and autumn. The serum 25-OH VitD deficiency degree in the patients with diabetes, hypertension and hypothyroidism was more severe, and which in hyperthyroidism and osteoporosis was mild. Conclusion Vit D deficiency in the patients with endocrine disorders in Yinchuan area of Ningxia is generally ubiquitous, which needs to pay more attention and actively treatment.