乳腺癌改良根治术结合背阔肌带蒂皮瓣移植治疗局部晚期乳腺癌患者的临床价值

Clinical Value of Modified Radical Mastectomy Combined with Pedicled Latissimus Dorsi Flap Transplantation for the Treatment of Locally Advanced Breast Cancer

目的探讨乳腺癌改良根治术结合背阔肌带蒂皮瓣移植治疗局部晚期乳腺癌患者的临床价值。方法选取局部晚期乳腺癌患者100例,随机分为实验组和对照组各50例。实验组行改良乳腺癌根治术结合背阔肌带蒂皮瓣移植术,对照组行传统改良乳腺癌根治术。比较两组患者的术后术肢肩关节活动度、日常生活活动能力、术后并发症、癌细胞转移情况及1年存活率。结果实验组患者的术后术肢肩关节活动度在四个方向均显著优于对照组(P<0.05)。两组术后并发症发生率无统计学差异(P>0.05)。实验组的癌细胞转移人数显著少于对照组(P<0.05),1年存活率显著高于对照组(P<0.05)。结论乳腺癌改良根治结合背阔肌带蒂皮瓣移植术治疗局部晚期乳腺癌并发症少,可延长术后生存期,具有较高的临床价值。

Objective To explore the clinical value of modified radical mastectomy combined with pedicled latissimus dorsi flap transplantation for the treatment of locally advanced breast cancer. Methods 100 cases of patients with locally advanced breast cancer were selected and randomly divided into two groups, with 50 cases in each group. The experimental group was treated with modified radical mastectomy combined with pedicled latissimus dorsi flap transplantation, while the control group was treated with conventional modified radical mastectomy. The postoperative activity of shoulder joint of affected side, activities of daily living, complications, metastasis of cancer cells and 1-year survival rate were compared between two groups. Results The postoperative activities of shoulder joint of affected side in four directions of experimental group were significantly better than those of control group （all P 〈0.05）. No statistical difference was found between two groups in the incidence of postoperative complications （P〉0.05）. The cases of metastasis of cancer cells in experimental group was more than that of control group （P〈0.05）, and the 1-year survival rate of experimental group was significantly higher than that of control group （P〈0.05）. Conclusions Modified radical mastectomy combined with pedicled latissimus dorsi flap transplantation for the treatment of locally advanced breast cancer can prolong postoperative survival period, and has few complications and high clinical value.