活血行气中药联合镇痛药治疗膝骨关节炎关节镜术后疼痛及对炎性因子影响

Effects of Chinese Herbal Medicine for Activating Blood Circulation and Invigorating Qi on Arthritis after Arthroscopic Surgery

目的:观察活血行气止痛中药联合镇痛药治疗膝骨关节炎(KOA)行关节镜术后疼痛患者的临床疗效及对炎性因子的影响。方法:将60例符合诊断标准的KOA患者随机分为2组,每组30例,两组患者无显著差异,具有可比性。对照组针对性给予芬太尼透皮贴剂、地佐辛注射液、盐酸昂丹司琼胶囊,治疗组在对照组基础上给予口服活血行气止痛的中药进行治疗。治疗时间为7 d,观察治疗前后两组患者的VAS疼痛评分、关节液白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平、临床总有效率。结果:对照组和治疗组患者的VAS疼痛评分均显著降低(P<0.05),治疗组的IL-6、TNF-α显著降低(P<0.05),而治疗组的各项指标改善的更显著;治疗组患者总有效率显著高于对照组(P<0.05)。结论:活血行气止痛中药联合镇痛药治疗膝骨关节炎行关节镜术后疼痛患者可以取得较好的疗效,并改善患者关节炎症状态。

Objective： To observe the clinical effect and the effect of inflammatory factors on patients with pain after knee arthroscopy in the treatment of knee osteoarthritis （ KOA ）with traditional Chinese herbal medicine combined with analgesics. Methods ： Sixty patients with KOA were randomly divided into two groups, 30 patients in each group, 2 patients were not significantly different, comparable. The control group was treated with fentanyl transdermal patch, dizzozin injection and ondansetron hydroehloride capsules. The treatment group was treated with traditional Chinese medicine of activating blood circulation, invigorating Qi and stopping pain on the basis of the control group. The duration of treatment was 7 days. The VAS pain score, IL-6 and TNF- ct in the two groups before and after treatment were observed and the clinical curative effect was evaluated. Results ： The levels of IL-6 and TNF- ct in the treatment group were significantly lower than those in the control group （ P〈0.05 ）, while those in the treatment group were significantly improved The total effective rate was significantly higher than the control group （ P〈0.05 ）. Conclusion ： Activating blood circulation, invigorating Qi and stopping pain medicine combined with analgesic treatment of knee osteoarthritis after arthroscopic pain patients can achieve better results, and improve patients＇ inflammatory state.