COP9信号复合体在真菌生长发育及次级代谢过程中的作用研究进展

Research Progress on the Role of COP9 Signalosome in Growth,Development and Secondary Metabolism of Fungus

COP9信号复合体(CSN)是真核生物中高度保守的蛋白复合物,参与调控整个生命过程,目前的研究主要集中在人类和动植物中,而关于真菌COP9信号复合体的研究主要集中在几个模式真菌,其他真菌相关研究较少,国内对真菌COP9信号复合体的研究更少。从真菌COP9信号复合体的组成和结构特征、调控真菌生长发育的机制以及协调次级代谢等方面进行综述,并对其现存的疑惑进行了分析,以期为进一步研究COP9信号复合体在真菌中的作用提供参考。

The COP9 signalosome （ CSN ） is a highly conserved protein complex in eukaryotes, ,arid is involved in the control of the whole life. At present, the researches on COP9 signalosome are mainly concentrated in humans, animals and plants. The research on fungal COP9 signalosome is mainly focused on several patterns of fungi, relatively few on other fungi, and even less in China. In this paper, we summarized the composition and structure traits, the related regulation mechanisms for growth and development, and the coordination of secondary metabolism of fungal COP9 signalosome. Further, we analyzed the existing doubts about COP9 signalosome, aiming at providing references for further studying the functions of COP9 signalosome in fungus.