电针治疗良性前列腺增生及对患者雌雄激素水平的影响

Impacts of electroacupuncture on benign prostatic hyperplasia and the levels of estrogen and androgen in patients

目的:探讨电针对良性前列腺增生患者的疗效及对激素水平的影响。方法:将60例患者随机分为电针组和药物组,每组30例。电针组采用电针中极、曲骨穴治疗,每日1次,每周5次;药物组口服盐酸坦洛新缓释胶囊0.2 mg,每日1次,两组均治疗6周。观察两组治疗前后血清睾酮(T)、雌二醇(E_2)水平及雌雄激素比(E_2/T)的变化,采用国际标准进行前列腺症状评分(IPSS)及阴茎勃起功能评分(IIEF5),并检测血清前列腺特异抗原(PSA)及两组患者的不良反应情况,比较两组的临床疗效。结果:电针组治疗前后血清T、E_2、E_2/T比较差异均无统计学意义(均P>0.05),药物组治疗前后E_2/T比较差异有统计学意义(P<0.05);两组间血清T、E_2、E_2/T比较差异均无统计学意义(均P>0.05)。电针组IPSS评分较治疗前降低(P<0.05),药物组IPSS评分与治疗前比较差异无统计学意义(P>0.05);治疗后电针组IPSS评分低于药物组(P<0.05);电针组治疗后症状严重者明显减少,整体情况优于药物组(P<0.05)。两组IIEF5评分、PSA值治疗前后及组间比较差异均无统计学意义(均P>0.05)。电针组总有效率为60.7%(17/28),明显优于药物组的30.8%(8/26,P<0.05)。结论:电针中极、曲骨穴能明显减轻患者临床症状,疗效优于口服盐酸坦洛新缓释胶囊,对患者血清T、E_2水平未见明显影响。

Objective To discuss the therapeutic effects of electroacupuncture on benign prostatic hyperplasia and the impacts on hormone levels in the patients. Methods Sixty patients were randomized into an electroacupuncture group and a medication group, 30 cases in each one. In the electroacupuncture group, electroacupuncture was applied to Zhongji（CV 3） and Qugu（CV 2）, once a day, 5 times a week. In the medication group, tamsulosin hydrochloride sustained-release capsules were prescribed for oral administration, 0.2 mg, once a day. The duration of treatment was 6 weeks in both of the two groups.The changes in serum testosterone（T）, estradiol（E2） and E2/T, the international prostate symptom score（IPSS） and its erectile function score（IIEF5） and serum prostate specific antigen（PSA） as well as the adverse reactions were observed before and after treatment in the two groups. The clinical therapeutic effects were compared between the two groups. Results Before and after treatment, the differences in serum T, E2 and E2/T were not significant in the electroacupuncture group（all P〉0.05）;the difference in E2/T was significant in the medication group（P〈0.05）. The differences in serum T, E2 and E2/T were not significant between the two groups（all P〉0.05）. IPSS was reduced as compared with that before treatment in the electroacupuncture group（P〈0.05） and was not different significantly as compared with that before treatment in the medication group（P〉0.05）. The difference was significant in comparison of the two groups after treatment（P〈0.05）, and the electroacupuncture group was better. After treatment, the symptom severity was reduced apparently in the electroacupuncture group and the overall situation was better than that in the medication group（P〈0.05）. IIEF5 score and PSA were not different significantly before and after treatment in the two groups and between the two groups（all P〉0.05）. The total effective rate was 60.7%（17/28） in the electroacupuncture group, apparently better than 30.8%（8/26, P〈0.05） in the the medication group.Conclusion Electroacupucnture at Zhongji（CV 3） and Qugu（CV 2） apparently relieves the symptoms in the patients and the therapeutic effects are better than the oral administration of tamsulosin hydrochloride sustained-release capsules, but electroacupuncture has not apparent impacts on serum T and E2 levels.