宽心合剂对于椎基底动脉成形术后再狭窄的影响

Soothing Agent on Restenosis after Basilar Artery Angioplasty

目的:探讨分析宽心合剂对椎基底动脉成形术后再狭窄的影响。方法:随机选取2014年10月—2015年12月来医院行椎基底动脉成形术的患者72例,并随机分为观察组和对照组,每组36例,术后给予两组患者相同的常规抗血小板治疗,观察组在此基础上口服宽心合剂,术后6个月观察两组患者的再狭窄情况。结果:术后6个月后,患者复查头CTA或DSA,观察组有3例发生再狭窄,而对照组有7例,观察组发生再狭窄的人数显著少于对照组,差异具有统计学意义(P<0.05),两组患者经治疗后,TXB2水平均得到增高,术后2月最高,但两组对比无明显差异(P>0.05);两组患者术后血浆t PA的活性均高于治疗前,术后1月最高,然后逐渐降低,观察组血浆t PA活性的升高情况较对照组更加明显,时间持续更长,差异具有统计学意义(P<0.05)。结论:椎基底动脉成形术患者在常规抗血小板治疗的基础上服用宽心合剂,能够有效抑制再狭窄的情况,值得在临床上推广应用。

Objective： To investigate the impact of Soothing Agent on restenosis after basilar artery angioplasty. Methods： From October 2014 to December 2015 in our hospital,72 patients with basilar artery forming surgery were randomly divided into observation group and control group,36 cases in each. After giving the same conventional anti-platelet treatment,observation group was treated with soothing agent. After 6 months,observe patients＇ restenosis on this basis. Results： After 6 months later,by CTA or DSA,the observation group had 3 patients restenosis while the control group had7. The observation group＇s cases of restenosis wre significantly less than the control group＇s and the difference was statistically significant（ P〈0. 05）. After treatment,two groups＇ TXB2 levels were increased and up to the highest 2months later,but there was no significant difference between two groups（ P〉0. 05）. The postoperative plasma t PA activity was higher and the highest 1 month later and then gradually decreased. The observation group＇s plasma t PA activity was significantly more than the control group＇s and lasted longer. The difference was statistically significant（ P〈0. 05）.Conclusion： The basilar artery angioplasty in patients taking soothing agent based on conventional antiplatelet therapy can effectively inhibit restenosis situation,worthy of clinical application.