解毒凉血法治疗乙型肝炎加急性肝衰竭的疗效评价及机制研究

Evaluation of Therapeutic Effect of Detoxification and Cooling Blood Therapy on Hepatitis B and Acute Hepatic Failure and Its Mechanism

目的:探析乙型肝炎加急性肝衰竭病症在解毒凉血治疗下的临床疗效。方法:将2014年12月—2015年12月于医院接受治疗的90例乙型肝炎加急性肝衰竭患者选为分析的对象,并随机将其分均为对照组与观察组,对照组予以西药治疗,观察组在对照组的基础上予以解毒凉血法治疗,比较两组患者的临床疗效、肝功能(凝血酶原活动度(PTA)、总胆红素(TBIL)、血清白蛋白(ALB))情况、并发症的发生情况等。结果:观察组的治疗总有效率(97.78%)高于对照组(75.56%),肝功能指标:PTA(74.25±10.20)%、TBIL(121.85±30.10)μmol/L、ALB(45.56±6.23)g/L指标均较对照组的PTA(50.45±10.25)%、TBIL(242.65±30.15)μmol/L、ALB(32.78±6.10)g/L指标趋于正常值,且并发症的发生率(6.67%)低于对照组(35.56%),比较的结果均具有统计学意义(P<0.05)。结论:乙型肝炎加急性肝衰竭病症在解毒凉血治疗下的疗效尤为显著,不仅可以有效地改善患者的肝功能,而且降低并发症的发生率,值得临床广泛应用。

Objective： To explore the clinical effect of detoxification and cooling blood therapy on hepatitis B with acute liver failure. Methods： Ninety patients with hepatitis B and acute liver failure who were treated in our hospital from December 2014 to December 2015 were randomly selected and divided into control group and observation group. The control group was given Western medicine and the observation group added detoxification and cooling blood therapy. The two groups＇ PTA,total bilirubin（ TBIL）,serum albumin（ BIL） and serum albumin（ P〈0. 05）,the occurrence of complications and so on were compared. Results： The total effective rate of the treatment group（ 97. 78%） was higher than that of the control group（ 75. 56%）. The liver function index PTA（ 74. 25 ± 10. 20） %,TBIL（ 121. 85 ± 30. 10） μmol/L,ALB（ 45. 56 ± 6. 23）（ P〈0. 05） and the index of ALB（ 32. 78 ± 6. 10） g/L were more normal than those of the control group（ P〈0. 05）. The incidence of complication was 6. 67（ P〈0. 05）,lower than that of the control group（ 35. 56%） and the results were statistically significant（ P〈0. 05）. Conclusion： Hepatitis B plus acute liver failure is particularly effective in the treatment of detoxification and cooling blood which not only can improve the liver function of patientsbut also can reduce the incidence of complications. It is worthy of clinical application.