α-L-岩藻糖苷酶与小于胎龄儿宫内发育及其糖脂代谢的相关性

A correlated study between-L-alpha glucosidase and intrauterine growth and glucose and lipid metabolism in fetus below the gestational age

目的:探讨小于胎龄儿(SGA)血α-L-岩藻糖苷酶(AFU)水平变化及其与糖脂代谢的相关性。方法:以125例小于胎龄儿(SGA)及患新生儿湿肺的128例适于胎龄儿(AGA)为研究对象,采用病例对照研究的方法,分析比较两组患儿生后24h内血AFU及糖脂代谢水平;分析SGA患儿AFU水平变化与其糖脂代谢改变的相关性。结果:SGA生后24内血AFU、高密度脂蛋白、载脂蛋白A及脂蛋白a显著低于对照组,差异有统计学意义(P<0.05);相关分析显示,SGA新生儿血AFU水平与血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、及载脂蛋白A水平正相关(P<0.05),与甘油三脂水平负相关(P<0.05)。结论:SGA生后即存在糖脂代谢紊乱,其血中AFU含量降低并与其糖脂代谢水平有相关性。

Objective To investigate the change of serum alpha -L- fucosidase （AFU） and its correlation with the blood glucose and lipid level in small for gestational age （SGA） fetuses. Methods 125 SGA fetuses and 128 fetuses in appropriate for gestational age （AGA） with wet lung were treated in our hospital and were investigated as case control study. The serum of AFU, blood glucose and lipid were measured and compared within 24 hours after birth in these 2 groups. Results Comparing with the AGA infants, the SGA babies had lower level of serum AFU, high density lipoprotein, apolipoprotein A and apolipoprotein B （P 〈 0.05）. The correlation analysis showed that the serum AFU level has positive correlation with blood glucose, total cholesterol, high density lipoprotein, low density lipoproteinand apolipoprotein A （P 〈 0.05 ）, while it has negative correlation with serum triglycerides in SGA （P 〈 0.05）. Conclusions The SGA infants have lower level of serum AFU and lipid metabolic disorders after birth, and its serum AFU level has correlation with its blood glucose and lipid level.